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Cefotiam

Cefotiam Structure
CAS No.
61622-34-2
Chemical Name:
Cefotiam
Synonyms
SCE 963;Texodil;CEFOTIAM;Taketiam;cgp14221e;Pansporin T;CEFOTIAM HCL;(6r-trans)--oxo;Cefotiam USP/EP/BP;Pansporin：Pansporine
CBNumber:
CB7367629
Molecular Formula:
C18H23N9O4S3
Molecular Weight:
525.63
MOL File:
61622-34-2.mol
Modify Date:
2024/4/12 23:00:59
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Cefotiam Properties

Boiling point 843℃
Density 1.80±0.1 g/cm3(Predicted)
RTECS XI0366000
Flash point >110°(230°F)
storage temp. 2-8°C
pka 2.57±0.50(Predicted)
Water Solubility Soluble
CAS DataBase Reference 61622-34-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501

Cefotiam Chemical Properties,Uses,Production

Uses

Antibacterial

Definition

ChEBI: A cephalosporin with ({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl and (2-amino-1,3-thiazol-4-yl)acetamido substituents at positions 3 and 7, respectively, of the cephem skeleton. A third generation beta-lactam cephalospo in antibiotic, it is active against a broad spectrum of both Gram positive and Gram negative bacteria.

Antimicrobial activity

A semisynthetic cephalosporin formulated as the dihydrochloride for injection and as a prodrug ester, cefotiam hexetil, for oral administration. Activity is similar to that of cefuroxime, but it is somewhat more active against a range of enterobacteria .
A 30-min intravenous infusion of the dihydrochloride produces a peak serum concentration of 35 mg/L; the corresponding concentration after a 1 g intramuscular dose is 17 mg/L. Oral absorption of the hexetil ester is around 65%. Food delays absorption of the ester. The plasma half-life is 0.6–1.1 h. Around 40% is bound to plasma protein. Urinary excretion is almost complete 4 h after the end of intravenous infusion, but only 50–67% is recovered unchanged; there is substantial non-renal elimination and some evidence of saturation of renal tubular excretion at doses above 2 g. In anuria the plasma elimination half-life rises to 13 h and plasma and renal clearances parallel creatinine clearance. A small amount is excreted in bile. In patients with cholelithiasis given 0.5 or 1 g intravenously, mean concentrations in gallbladder bile and gallbladder wall 30 min after the dose were around 17 and 32 mg/L, respectively. In patients with normal liver function, hepatic bile concentrations can exceed 1 g/L.
It is generally well tolerated and has been used successfully to treat lower respiratory infections, skin and soft-tissue infection. It is not widely used, but is available in Japan and some other countries.

Cefotiam Preparation Products And Raw materials

Raw materials

Cefotiam Hydrochloride 2-N-BUTOXYETHYL METHACRYLATE MERCAPTANS 1H-TETRAZOLE Sodium azide
(+)-MENTHYL CHLOROFORMATE Carbon dioxide Ethyl isothiocyanate Magnesium sulfate 2-Aminothiazole-4-acetic acid
Hydroxylamine hydrochloride Triethylamine AMBERLITE 1-[2-(Dimethylamino)ethyl]-1H-tetrazole-5-thiol N-Hydroxysuccinimide
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Preparation Products

Cefotiam Suppliers

Global( 86)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Shaanxi TNJONE Pharmaceutical Co., Ltd +8618740459177 China 1142 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29897 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418671 China 34571 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-89586680 +86-18192503167 China 9030 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 58
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
Shaanxi Dideu Medichem Co. Ltd 58
AFINE CHEMICALS LIMITED 58

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61622-34-2(Cefotiam)Related Search:

2-(2-Aminothiazol-4-yl)glyoxylic acid N-ACETYL-L-TYROSINE ETHYL ESTER 4-Dimethylaminobenzoic acid 4-Dimethylaminopyridine Glycine
Acetyl chloride 4-Dimethylaminobenzaldehyde 3-Dimethylaminopropylamine 6-Aminocaproic acid Acetylacetone
ALTRENOGEST Acetyl coenzyme A sodium salt Tris(hydroxymethyl)aminomethane CEFOTIAM 2HCL,cefotiam hydrochloride 2-Dimethylaminoethanol
CefotiaM Hexetil Hydrochloride 2-(2-aminothiazole-4-yl)acetic acid hydrochloride (intermediate of cefotiam) cefotiam hexetil hydrochloride
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8-[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino-4-[[1-(2-dimethylaminoethyl)tetrazol-5-yl]sulfanylmethyl]-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid (6r-trans)--oxo )acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1h-tetrazol-5-yl)thio)methyl)-8 cgp14221e CEFOTIAM CEFOTIAM HCL 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, (6R,7R)- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, (6R-trans)- SCE 963 Cefotiam (base and/or unspecified salts) (6R-trans)-7-[[(2-Amino-4-thiazlyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-y1]thio]methyl]-8-oxo-5-thia-1-azabi-cyclo[4.2.0]oct-2-ene-2-carboxylic acid Pansporin T Pansporin：Pansporine Taketiam Texodil (6R,7R)-7α-[(2-Amino-4-thiazolyl)acetylamino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(2-aMino-4-thiazolyl)acetyl]aMino]-3-[[[1-[2-(diMethylaMino)ethyl]-1H-tetrazol-5-yl]thio]Methyl]-8-oxo-, (6R,7R)- Cefotiam Crude N-acetylneuraminic Cefotiam USP/EP/BP 61622-34-2