Monomethyl fumarate
- CAS No.
- 2756-87-8
- Chemical Name:
- Monomethyl fumarate
- Synonyms
- (E)-4-Methoxy-4-oxobut-2-enoic acid;Fumaric acid monomethyl ester;Methyl hydrogen fumarate;4-Methoxy-4-oxobut-2-enoic acid;Monomethyl fumarate;TAK438 Impurity 110;Methylhydrogenfumarat;MonomethylFumarate>Vonoprazan Impurity 110;Mono-Methyl fuMarate 97%
- CBNumber:
- CB7505423
- Molecular Formula:
- C5H6O4
- Molecular Weight:
- 130.1
- MOL File:
- 2756-87-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/11/29 18:07:07
| Melting point | 144-145 °C (lit.) |
|---|---|
| Boiling point | 250.0±23.0 °C(Predicted) |
| Density | 1.37 g/cm3 |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 3.40±0.10(Predicted) |
| form | Solid |
| color | Off-White |
| λmax | 209nm(MeOH)(lit.) |
| CAS DataBase Reference | 2756-87-8(CAS DataBase Reference) |
Monomethyl fumarate price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 651419 | mono-Methyl fumarate 97% | 2756-87-8 | 1G | ₹2641.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 92571 | mono-Methyl fumarate certified reference material, TraceCERT? | 2756-87-8 | 50MG | ₹7306.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 651419 | mono-Methyl fumarate 97% | 2756-87-8 | 10G | ₹12979.18 | 2022-06-14 | Buy |
| TCI Chemicals (India) | M2413 | Monomethyl Fumarate min. 98.0 % | 2756-87-8 | 5G | ₹7200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M2413 | Monomethyl Fumarate min. 98.0 % | 2756-87-8 | 25G | ₹15600 | 2022-05-26 | Buy |
Monomethyl fumarate Chemical Properties,Uses,Production
Description
Monomethyl fumarate (MMF), a bioactive metabolite of fumaric acid ester, is an immunotherapy for psoriasis that causes decreased production of Th1 cytokines and lymphocytopenia. Monomethyl fumarate was shown to decrease DC response to LPS and decreased IL-12p70 and IL-10 production.
Chemical Properties
Off-White Solid
Uses
Monomethyl fumarate is used to treat the relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. This medicine will not cure MS, but it may slow some of the disabling effects and decrease the number of relapses of the disease.
Fumaric Acid Monomethyl Ester is one of the most bioactive anti-psoriatic fumaric acid ester metabolite. Fumaric Acid Monomethyl Ester is potent nicotinic acid receptor agonist. Fumaric Acid Monomethy l Ester has also been shown to selectively stimulate of T helper 2 cytokine response.
Definition
ChEBI: Monomethyl fumarate is a dicarboxylic acid monoester resulting from the formal condensation of one of the carboxy groups of fumaric acid with methanol. Is is a metabolite of dimethyl fumarate and used for the the treatment of patients with relapsing multiple sclerosis (MS). It also induces the NFE2L2 (Nrf2) transcription factor by binding to KEAP1. It has a role as an immunomodulator, an antioxidant and a drug metabolite. It is an enoate ester, a methyl ester and a dicarboxylic acid monoester. It derives from a fumaric acid.
Preparation
Monomethyl fumarate was synthesized by maleic anhydride and methanol. monomethyl fumarate could inhibit the growth of mold, and the storage time of feed could be prolonged.
Synthesis Reference(s)
The Journal of Organic Chemistry, 23, p. 1559, 1958 DOI: 10.1021/jo01104a608
Monomethyl fumarate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| Honour Lab Limited | +919845977466 | Telangana, India | 164 | 58 | Inquiry |
| MSN LIFE SCIENCES PRIVATE LTD | +91 84523 34200 | New Delhi, India | 104 | 58 | Inquiry |
| HONOUR LAB LTD | +91-40-23710405 | New Delhi, India | 39 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Varanous Labs Pvt Ltd | 58 |
| Honour Lab Limited | 58 |
| MSN LIFE SCIENCES PRIVATE LTD | 58 |
| HONOUR LAB LTD | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| SynZeal Research Pvt Ltd | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
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