Nefazodone hydrochloride

Nefazodone hydrochloride Properties

Melting point	186-188°C
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO: ~11 mg/mL at 60 °C
form	solid
color	white
λmax	248nm(MeOH)(lit.)
Merck	14,6438
CAS DataBase Reference	82752-99-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Safety Statements	22-24/25
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS	XZ5483009
HS Code	2933595960

Nefazodone hydrochloride price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	N5536	Nefazodone hydrochloride ≥98% (HPLC), solid	82752-99-6	10MG	₹13671.98	2022-06-14	Buy
Sigma-Aldrich(India)	N5536	Nefazodone hydrochloride ≥98% (HPLC), solid	82752-99-6	50MG	₹54752.85	2022-06-14	Buy
Sigma-Aldrich(India)	5.08148	Nefazodone Hydrochloride - CAS 82752-99-6 - Calbiochem	82752-99-6	10MG	₹14100	2022-06-14	Buy
TCI Chemicals (India)	N1030	Nefazodone Hydrochloride	82752-99-6	200MG	₹2000	2022-05-26	Buy
TCI Chemicals (India)	N1030	Nefazodone Hydrochloride	82752-99-6	1G	₹7900	2022-05-26	Buy

Product number	Packaging	Price	Buy
N5536	10MG	₹13671.98	Buy
N5536	50MG	₹54752.85	Buy
5.08148	10MG	₹14100	Buy
N1030	200MG	₹2000	Buy
N1030	1G	₹7900	Buy

Nefazodone hydrochloride Chemical Properties,Uses,Production

Description

Nefazodone, a second generation trazodone type antidepressant, was launched in Canada. Nefazodone acts as both a potent 5-HT₂ receptor antagonist and as a serotonin (5-HT) reuptake inhibitor. This combination effect appears to enhance 5-HT_IA-mediated neurotransmission. Distinct from the first generation agents such as tricyclic antidepressants, nefazodone has very selective serotonergic effects with negligible affinity for cholinergic and histamine receptors, and low affinity for a₁ -adrenergic receptors. Therefore, it has a superior toxicity profile that does not produce agitation, insomnia, and lacks cardiac side effects.

Chemical Properties

White Solid

Uses

A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.

General Description

Nefazodone, formerly sold under the brand names Serzone, Dutonin, and Nefadar, is an antidepressant that has been discontinued due to the incidence of severe liver damage. This certified Snap-N-Spike^; solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing.

Biological Activity

Serotonin 5-HT 2A receptor antagonist (K i = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC 50 values are 290 and 300 nM respectively). Displays no activity at 5-HT 1B and 5-HT 1D receptors. Active in models predictive of antidepressant potential.

Nefazodone hydrochloride Preparation Products And Raw materials

Raw materials

Thionyl chloride Triethyl orthopropionate Α-PHENOXYPROPIONIC ACID HYDRAZINE Sodium nitrite

1-(3-Chlorphenyl)piperazine

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Preparation Products

Nefazodone hydrochloride Suppliers

Global( 206)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Medilink Pharmachem	+91 (79) 3007-0133	New Delhi, India	424	50	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Primarius Custom Synthesis P. Ltd.	+91 (265) 233-1730	New Delhi, India	43	0	Inquiry
Pharmaffiliates Analytics & Synthetics (P) Ltd.	91-172-5066494	Haryana, India	631	58	Inquiry
Shivam Pharma Chemicals	91-22-26403900	Maharashtra, India	656	58	Inquiry
Dharmanandan Export Pvt., Ltd.	91-79-48402200	Gujarat, India	161	58	Inquiry
Medkem Laboratories	91-40-23700606	Andhra Pradesh, India	297	58	Inquiry

Supplier	Advantage
Medilink Pharmachem	50
TCI Chemicals (India) Pvt. Ltd.	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Primarius Custom Synthesis P. Ltd.	0
Pharmaffiliates Analytics & Synthetics (P) Ltd.	58
Shivam Pharma Chemicals	58
Dharmanandan Export Pvt., Ltd.	58
Medkem Laboratories	58

82752-99-6(Nefazodone hydrochloride)Related Search:

Naphazoline hydrochloride Topotecan hydrochloride Furazolidone Naphazoline Triadimefon

Trazodone Nefazodone Related Compound B,Nefazodone Related Compound B NEFAZODONE,Nefazodone base,Nefazodone (base and/or unspecified salts),NEFAZODONE,Nefazodone base,Nefazodone (base and/or unspecified salts) 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Nefazodone Related Compound A,Nefazodone Related Compound A

HYDROXY NEFAZODONE HCL,HYDROXY NEFAZODONE HCL Nefazodone hydrochloride NEFAZODONE , TRAZODONE,NEFAZODONE , TRAZODONE HYDROXY NEFAZODONE-D5 HCL,HYDROXY NEFAZODONE-D5 HCL 5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazole-3-one (intermediate of nefazodone hcl)

Nefazodone Hcl

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NEFAZODONE-D5 HCL 3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride Nefazodone HCl Nefazodone hydrochloride NEFAZODONE BMY-13754, MJ-13754-1, Serzone, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride 2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride Nefazodone Hydrochloride (200 mg) 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one BMY 13754-1 Serazone Nefazodone hydrochloride API 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one hydrochloride Nefazodone hydrochlo 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)- >=98% (HPLC) 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4 )-trans-4-(3-cyanophenyl)pyrrolidine-3-carboxylic acid &ge 3-[(3-Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate &ge Na-Fmoc-Nb-(N-Boc-amino-oxyacetyl)-L-2,3-diaminopropionic acid &ge Fmoc-1-amino-4-oxo-cyclohexane carboxylic acid &ge 8-Methoxy-1H-benzo[d][1,3]oxazine-2,4-dione &ge Fmoc-D-2-amino-4-bromo-4-pentenoic acid &ge 2-Amino-5-(4-fluorophenyl)-1,3,4-thiadiazole &ge 3-(4-Methoxyphenyl)pyrazole &ge Boc-N-ethyl glycine &ge Boc-D-a-aminobutyric acid &ge Na-Fmoc-Ne-Z-L-lysine &ge (1,2-Dibromoethyl)benzene &ge Na-Acetyl-L-ornithine &ge Na-Acetyl-D-tryptophan &ge 5,6-Dimethoxyindole &ge Z-L-serine amide &ge TFA &ge Gly-OBg· Boc-4-iodo-L-phenylalanine &ge Boc-S-tert-butyl-L-cysteine dicyclohexylammonium salt &ge D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid &ge (3R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid tert-butyl ester hydrochloride &ge 4-Acetamido-2-methylbenzoic acid &ge Methyl 2,4-dioxo-4-(2-thienyl)butanoate &ge 3-(4-Fluorophenyl)-1H-pyrazole-5-carbohydrazide &ge (3-Benzothienyl)-L-b-homoalanine hydrochloride &ge 2-(2H-Tetrazol-5-yl)pyridine &ge (S)-Fmoc-3-amino-2-benzyl-propionic acid &ge 7-Methoxy-1H-indole-3-carbaldehyde &ge 2-Chloro-6-methyl-4-(trifluoromethyl)pyridine &ge 5-Amino-2-methylpyridine &ge Ethyl 3-Amino-3-ethoxyacrylate hydrochloride &ge Fmoc-(4-aminomethyl) benzoic acid &ge Fmoc-3,4-dichloro-L-b-homophenylalanine &ge 1,3-Diacetylindole &ge Fmoc-3-nitro-D-phenylalanine &ge 4-Amino-D-phenylalanine hydrochloride &ge Fmoc-(R)-4-aminopimelic acid 1-tert-butyl ester &ge 5-Azacytidine &ge 1-(2-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbohydrazide &ge 5-(4-Bromophenyl)thiophene-2-carboxylic acid &ge