Nefazodone
- CAS No.
- 83366-66-9
- Chemical Name:
- Nefazodone
- Synonyms
- SERZONE;Dutonin;Nefadar;BMY-13754;NEFAZODONE;MJ-13754-1;MJ-13754-I;Nefazodone base;l)-5-ethyl-4-(2-phenoxyethyl)-;Nefazodone (base and/or unspecified salts)
- CBNumber:
- CB5144862
- Molecular Formula:
- C25H32ClN5O2
- Molecular Weight:
- 470.01
- MOL File:
- 83366-66-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/4 17:34:43
| Melting point | 180-182°C |
|---|---|
| Boiling point | 599.6±60.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ~11 mg/mL at 60 °C |
| form | solid |
| pka | pKa 6.5 (Uncertain) |
| color | white |
| CAS DataBase Reference | 83366-66-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Nefazodone(83366-66-9) |
Nefazodone Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
A selective serotonin 5-HT2 receptor antagonist. An antidepressant
Biological Functions
Although nefazodone (Serzone) is structurally related to trazodone, it is less sedating. It does not block α1- adrenoreceptors, and its use is not associated with priapism. Nefazodone inhibits the neuronal reuptake of serotonin and blocks 5HT2A receptors. Its short half-life requires dosing twice a day. Nefazodone is not associated with weight gain or sexual dysfunction. It inhibits the cytochrome P450 3A4 isoenzyme that is responsible for 50% of known oxidative metabolism, and therefore, nefazodone can elevate levels of drugs dependent on this pathway for metabolism.
Nefazodone Preparation Products And Raw materials
Raw materials
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Global( 60)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 8673 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
83366-66-9(Nefazodone)Related Search:
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3h-1,2,4-triazol-3-one,2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propy
l)-5-ethyl-4-(2-phenoxyethyl)-
BMY-13754
SERZONE
MJ-13754-1
NEFAZODONE
2-[3-[4-(3-CHLOROPHENYL)-1-PIPERAZINYL]PROPYL]-5-ETHYL-2,4-DIHYDRO-4-(2-PHENOXYETHYL)-3H-1,2,4-TRIAZOL-3-ONE HYDROCHLORIDE
Nefazodone base
2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one, Hydrochloride
3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-
Nefazodone (base and/or unspecified salts)
Dutonin
MJ-13754-I
2-[3-[4-(3-Chlorophenyl)piperazino]propyl]-4-(2-phenoxyethyl)-5-ethyl-2H-1,2,4-triazole-3(4H)-one
2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one
2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one
Nefadar
83366-66-9
C25H32ClN5O2
API
Intermediates & Fine Chemicals
Pharmaceuticals