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ACETYLSHIKONIN

CAS No.: 24502-78-1

Chemical Name:: ACETYLSHIKONIN

Synonyms: Nsc110199;ACETYLSHIKONIN;Shikonin acetate;Shikonin, acetyl;O-Acetylshikonin;(R)-acetyl shikonin;3-pentenyl]-5,8-dihydroxy-,(R)-;Racemic Acetyl Shikonin Labeled d7;1,4-Naphthalenedione,2-[1-(acetyloxy)-4-methyl-;2,3-dimethoxybenzoic acid 2-(dimethylamino)ethyl ester hydrochloride

CBNumber:: CB8317267

Molecular Formula:: C18H18O6

Molecular Weight:: 330.33

MOL File:: 24502-78-1.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:27

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ACETYLSHIKONIN Properties

Melting point	86°C
Boiling point	553.2±50.0 °C(Predicted)
Density	1.326±0.06 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
pka	7.12±0.20(Predicted)
color	Brown to khaki
Stability	Hygroscopic
LogP	2.700 (est)
CAS DataBase Reference	24502-78-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Risk Statements	36/37/38
Safety Statements	26-36/37/39
Toxicity	mouse,LD50,intraperitoneal,41mg/kg (41mg/kg),BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)BEHAVIORAL: ATAXIA,Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 73, Pg. 193, 1977.

ACETYLSHIKONIN Chemical Properties,Uses,Production

Chemical Properties

Acetylshikonin is a biologically active compound with anti-cancer and anti-inflammatory activity, which is isolated from the roots of Lithospermum erythrorhizoma.

Biological Activity

Acetylshikonin is one naphthoquinone derivative isolated from the Lithospermum erythrorhizon, exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC50 of over 20 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and angiogenic factors.
Acetylshikonin inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated.
Certain shikonin derivatives(such as Acetyl shikonin) act as modulators of the Nur77-mediated apoptotic pathway and identify a new shikonin-based lead that targets Nur77 for apoptosis induction.
Acetylshikonin, shikonin, and alkannin have accelerative effect on the proliferation of granulation tissue in rats.
Acetylshikonin isolated from Arnebia euchroma (Royle) Johnst cell suspension cultures exhibits specific in vivo and in vitro antitumor effects.
Acetylshikonin has inhibitory effect on the edematous response is due neither to the release of steroid hormones from the adrenal gland nor to the glucocorticoid activity, but probably partly to the suppression of mast cell degranulation and partly to protection of the vasculature from mediator challenge.
Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.

ACETYLSHIKONIN Preparation Products And Raw materials

Raw materials

Preparation Products

ACETYLSHIKONIN Suppliers

Global( 171)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	China	1000	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29901	58	Inquiry
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	CHINA	1824	58	Inquiry
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	China	3424	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	China	12261	58	Inquiry
Hubei Ipure Biology Co., Ltd	+8613367258412	China	10326	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	China	34571	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	China	52861	58	Inquiry
Hebei Duling International Trade Co. LTD	+8617333973358	China	15440	58	Inquiry

Supplier	Advantage
Shaanxi Haibo Biotechnology Co., Ltd	58
career henan chemical co	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Chongqing Chemdad Co., Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hebei Duling International Trade Co. LTD	58

ACETYLSHIKONIN Spectrum

ACETYLSHIKONIN(24502-78-1)¹HNMR ACETYLSHIKONIN(24502-78-1)¹³CNMR ACETYLSHIKONIN(24502-78-1)IR1

24502-78-1(ACETYLSHIKONIN)Related Search:

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Bengenin Isorhamnetin Taxifolin ARTEMISININ PINOCEMBRIN

Alkannin 5,8-Dihydroxy-1,4-naphthoquinone ISOVALERYLSHIKONIN ISOBUTYRYLSHIKONIN (BETA,BETA-DIMETHYLACRYL)SHIKONIN

ACETYLSHIKONIN (2-METHYL-N-BUTYRYL)SHIKONIN BETA-HYDROXYISOVALERYLSHIKONIN

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(+)-5,8-Dihydroxy-2-[(R)-1-acetoxy-4-methyl-3-pentenyl]-1,4-naphthoquinone (R)-1-(1,4-Dihydro-5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methyl-3-pentenyl=acetate 2-[(R)-1-Acetoxy-4-methyl-3-pentenyl]-5,8-dihydroxy-1,4-naphthoquinone O-Acetylshikonin 1,4-Naphthoquinone, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-, 2-acetate, (+)- Nsc110199 Shikonin, acetyl Shikonin acetate (+)-5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone2-acet 4-naphthalenedione,2-(1-(acetyloxy)-4-methyl-3-pentenyl)-5,8-dihydroxy-( 4-naphthoquinone,5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-2-acetate 1,4-NAPHTHALENEDIONE,2-[1-(ACETYLOXY)-4-METHYL-3-PENTENYL]-5,8-DIHYDROXY-, (R)- ACETYLSHIKONIN (R)-1-(5,8-Dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-Methylpent-3-en-1-yl acetate ACETYLSHIKONIN: 1,4-NAPHTHALENEDIONE,2-[1-(ACETYLOXY)-4-METHYL-3-PENTENYL]-5,8-DIHYDROXY-, (R)-, 1,4-Naphthalenedione,2-[1-(acetyloxy)-4-methyl- 3-pentenyl]-5,8-dihydroxy-,(R)- Racemic Acetyl Shikonin Labeled d7 2,3-dimethoxybenzoic acid 2-(dimethylamino)ethyl ester hydrochloride 1,4-Naphthalenedione, 2-[(1R)-1-(acetyloxy)-4-methyl-3-penten-1-yl]-5,8-dihydroxy- (R)-acetyl shikonin 24502-78-1 Miscellaneous Natural Products