Ethyl trifluoropyruvate
- CAS No.
- 13081-18-0
- Chemical Name:
- Ethyl trifluoropyruvate
- Synonyms
- ETHYL 3,3,3-TRIFLUORO-2-OXOPROPANOATE;ETHYL 3,3,3-TRIFLUOROPYRUVATE;E-TFPA;RARECHEM AL BI 1300;ETHYL TRIFLUOROPYRUVATE;Ethyltrifluoropyruvate98%;ETHYL 3,3,3-TRIFLUORO-2-O;Threefluorideethylpyruvate;Ethyl trifluoropyruvate 98%;Ethyl-trifluoroMethylpyruvate
- CBNumber:
- CB8333735
- Molecular Formula:
- C5H5F3O3
- Molecular Weight:
- 170.09
- MOL File:
- 13081-18-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/19 17:35:41
| Boiling point | 42 °C(lit.) |
|---|---|
| Density | 1.283 g/mL at 25 °C (lit.) |
| vapor pressure | 12.49hPa at 25℃ |
| refractive index |
n |
| Flash point | 88 °F |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Miscible with dichloromethane. |
| form | Liquid |
| color | Clear colorless to pale yellow |
| BRN | 2087388 |
| Stability | Moisture Sensitive |
| InChIKey | KJHQVUNUOIEYSV-UHFFFAOYSA-N |
| LogP | -0.05 |
| CAS DataBase Reference | 13081-18-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H302-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P233-P240-P301+P312-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,C,Xi | |||||||||
| Risk Statements | 10-22-36/37/38 | |||||||||
| Safety Statements | 26-37/39-16 | |||||||||
| RIDADR | UN 3272 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29183000 | |||||||||
| NFPA 704 |
|
Ethyl trifluoropyruvate price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 510254 | Ethyl 3,3,3-trifluoropyruvate 97% | 13081-18-0 | 5G | ₹2976.88 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T1434 | Ethyl Trifluoropyruvate min. 98.0 % | 13081-18-0 | 5G | ₹3800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T1434 | Ethyl Trifluoropyruvate min. 98.0 % | 13081-18-0 | 25G | ₹7700 | 2022-05-26 | Buy |
Ethyl trifluoropyruvate Chemical Properties,Uses,Production
Chemical Properties
Clear pale yellow liquid
Uses
Ethyl Trifluoropyruvate is used as a reagent in the preparation of potential biologically active compounds such as in the highly enantioselective organocatalytic hydroxyalkylation of indoles .
General Description
Ethyl 3,3,3-trifluoropyruvate is a trifluoromethylated compound. Enantioselective Friedel–Crafts alkylation of simple phenols and indoles with ethyl 3,3,3-trifluoropyruvate under different reaction conditions have been reported.
Synthesis
To 58 mL (1.0 mL/mmol) of acetonitrile, 10 g (58 mmol, 1.0 eq) of ethyl 3,3,3-trifluorolactate was added and dissolved therein.Furthermore, 11 g (67 mmol, 1.2 eq) of NaClO.5H2O was added, followed by stirring at 20° C. for 30 minutes.As the reaction-terminated liquid was analyzed by 19F-NMR, conversion was 100%, and selectivity was 98%.To the reaction-terminated liquid, 0.38 g (1.5 mmol, 0.026 eq) of sodium thiosulfate pentahydrate was added, followed by stirring, thereby quenching the remaining oxidation agent.Furthermore, 0.33 g (3.9 mmol, 0.067 eq) of sodium hydrogencarbonate and 10 g (70 mmol, 1.2 eq) of sodium sulfate were added, followed by stirring and then removing solid matter by filtration.As the filtrate was quantified with internal standard method (internal standard substance: α,α,α-trifluorotoluene) by 19F-NMR, Ethyl trifluoropyruvate was contained by 56 mmol (quantitative yield: 97%).By a simple distillation (up to 48° C./0.5 kPa) of the filtrate, 7.6 g of Ethyl trifluoropyruvate was obtained. 19F-NMR purity was 99% (40 mmol), and the total yield was 69%.
Ethyl trifluoropyruvate Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SRF Limited | +91-9810617574 +91-9650533660 | Haryana, India | 40 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Sumsahi Kemicals | 08048372113Ext 851 | Delhi, India | 16 | 58 | Inquiry |
| Avra Synthesis Pvt Ltd | +914027175796 | New Delhi, India | 1606 | 30 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| SRF LIMITED | +91-1493-245400 | New Delhi, India | 33 | 58 | Inquiry |
| Spectrochem Private Limited | 08048372608Ext 246 | Maharashtra, India | 1056 | 58 | Inquiry |
| ALTAIR ALCHEMY Laboratories | 91--9014276848 | Hyderabad, India | 324 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SRF Limited | 58 |
| JSK Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Sumsahi Kemicals | 58 |
| Avra Synthesis Pvt Ltd | 30 |
| Anand Agencies | 58 |
| SRF LIMITED | 58 |
| Spectrochem Private Limited | 58 |
| ALTAIR ALCHEMY Laboratories | 58 |
13081-18-0(Ethyl trifluoropyruvate)Related Search:
1of4
chevron_right