Sodium cloxacillin monohydrate
- CAS No.
- 7081-44-9
- Chemical Name:
- Sodium cloxacillin monohydrate
- Synonyms
- bactopen;Cloxacillin s;staphobristol-250;Cloxacillin sodium;orbeninsodiumhydrate;α-Amino-p-toluic acid;Cloxacillin sodium CRS;Oxacillin EP Impurity E;prostaphlin-amonohydrate;Cloxacillin Sodium(Oral)
- CBNumber:
- CB8705413
- Molecular Formula:
- C19H19ClN3NaO6S
- Molecular Weight:
- 475.88
- MOL File:
- 7081-44-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/7 13:47:35
| Melting point | 170℃ |
|---|---|
| Boiling point | 689℃ |
| Flash point | >110°(230°F) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | H2O: soluble50mg/mL |
| form | solid |
| color | White to Orange to Green |
| Water Solubility | Soluble in water |
| Merck | 13,2444 |
| BRN | 5403885 |
| CAS DataBase Reference | 7081-44-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H317-H319-H334-H335 | |||||||||
| Precautionary statements | P261-P280-P284-P304+P340-P305+P351+P338-P342+P311 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-42/43 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | XH8920000 | |||||||||
| HS Code | 29411099 | |||||||||
| NFPA 704 |
|
Sodium cloxacillin monohydrate price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C9393 | Cloxacillin sodium salt monohydrate β-lactamase-resistant antibiotic | 7081-44-9 | 1G | ₹5109.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1922 | Cloxacillin Sodium Pharmaceutical Secondary Standard; Certified Reference Material | 7081-44-9 | 500MG | ₹15826.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C9393 | Cloxacillin sodium salt monohydrate β-lactamase-resistant antibiotic | 7081-44-9 | 5G | ₹13509.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 46140 | Cloxacillin sodium salt monohydrate VETRANAL?, analytical standard | 7081-44-9 | 250MG | ₹6841.4 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C2244 | Cloxacillin Sodium Salt Monohydrate | 7081-44-9 | 1G | ₹4300 | 2022-05-26 | Buy |
Sodium cloxacillin monohydrate Chemical Properties,Uses,Production
Description
Cloxacillin was synthesized by Beecham Research Laboratories in 1962 starting with 6- aminopenicillanic acid. It was the first semisynthetic penicillin with a halogen atom in the side chain to be used clinically. It shows 5- to 20-fold stronger activity than methicillin and is twice as active as oxacillin against Staphylococcus aureus, including benzylpenicillin-resistant strains. Cloxacillin is highly stable against penicillinase and well absorbed by oral administration. It has been widely used, by oral and intramuscular administration, to treat internal, surgical, gynecological, and other infections caused by both benzylpenicillin-sensitive and benzylpenicillin-resistant bacteria.
Chemical Properties
White or almost white, hygroscopic, crystalline powder.
Uses
Penicillin antibacterial.
Contact allergens
Cloxacillin is a semisynthetic penicillin close to oxacillin. It induced contact dermatitis in a pharmaceutical factory worker with positive reactions to ampicillin, but not to penicillin. In cutaneous drug reactions such as acute generalized exanthematous pustulosis due to amoxicillin, cross-reactivity is frequent to cloxacillin (personal observations).
Clinical Use
The chlorine atom ortho to the position of attachment of thephenyl ring to the isoxazole ring enhances the activity ofcloxacillin sodium, [3-(o-chlorophenyl)-5-methyl-4-isoxazolyl]penicillin sodium monohydrate (Tegopen), over that ofoxacillin, not by increasing its intrinsic antibacterial activitybut by enhancing its oral absorption, leading to higher plasmalevels. In almost all other respects, it resembles oxacillin.
Safety Profile
Moderately toxic by intraperitoneal, intramuscular, subcutaneous, and intravenous routes. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of Cl-, NOx, Na2O, and SOx.
Sodium cloxacillin monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| AUROBINDO PHARMA LIMITED | +91 (40) 6672 1200 | New Delhi, India | 144 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Vindeca Life Sciences Private Limited | 08048372116Ext 830 | Delhi, India | 2 | 58 | Inquiry |
| Farmachem Life | 08048361335Ext 806 | Mumbai, India | 2 | 58 | Inquiry |
| Lexine Technochem Private Limited | 07942564658 | Vadodara, India | 69 | 58 | Inquiry |
| DSM Sinochem Pharmaceuticals India Private Limited | 08068970604Ext 805 | Haryana, India | 5 | 58 | Inquiry |
| Dots Lifescience Private Limited | 08068970619Ext 185 | Nagpur, India | 2 | 58 | Inquiry |
7081-44-9(Sodium cloxacillin monohydrate)Related Search:
1of4
chevron_right