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Cloxacillin-13C4 SodiuM Salt

Cloxacillin-13C4 SodiuM Salt Structure
CAS No.
642-78-4
Chemical Name:
Cloxacillin-13C4 SodiuM Salt
Synonyms
cloxapen;Sodium cloxacillin;Cloxacillin sodium salt;CLOXACILLIN SODIUM SALT HYDRATE;3-(o-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin sodium salt;5R;(2S;2-DPPE;Orbenin;tegopen
CBNumber:
CB5705412
Molecular Formula:
C19H19ClN3NaO5S
Molecular Weight:
459.88
MOL File:
642-78-4.mol
MSDS File:
SDS
Modify Date:
2024/7/26 15:15:06
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Cloxacillin-13C4 SodiuM Salt Properties

Melting point 170°C
storage temp. 2-8°C
solubility H2O: 50 mg/mL, clear, colorless
form Solid
color White to Off-White
Water Solubility Soluble in water
BCS Class 3
Stability Stable. Incompatible with strong oxidizing agents. Refrigerate.
CAS DataBase Reference 642-78-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08,GHS07
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P285-P304+P341-P342+P311-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
Hazard Codes  Xn
Risk Statements  36/37/38-42/43
Safety Statements  26-36-22
WGK Germany  2
RTECS  XH8920000
NFPA 704
0
2 0

Cloxacillin-13C4 SodiuM Salt price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 27555 Cloxacillin sodium salt ≥95.0% (HPLC) 642-78-4 1G ₹4860.43 2022-06-14 Buy
Sigma-Aldrich(India) 27555 Cloxacillin sodium salt ≥95.0% (HPLC) 642-78-4 5G ₹15425.63 2022-06-14 Buy
Product number Packaging Price Buy
27555 1G ₹4860.43 Buy
27555 5G ₹15425.63 Buy

Cloxacillin-13C4 SodiuM Salt Chemical Properties,Uses,Production

Description

Cloxacillin is a β-lactam antibiotic and a derivative of oxacillin . It is active against clinical isolates of the Gram-positive bacteria S. aureus and S. epidermidis (MICs = 0.004-0.4 and 0.1-0.8 μg/ml, respectively) but not 34 Gram-negative bacteria (MICs = >128 μg/ml for all). Cloxacillin binds to S. aureus penicillin-binding protein 1 (PBP1), PBP2, PBP3, and PBP4 (IC50s = 0.04, 0.12, 0.21, and 2.5 μg/ml, respectively). It also binds to recombinant type Ib penicillinase, as well as P. vulgaris and C. freundii cephalosporinase (Kis = 15, 0.27, and 0.027 μM, respectively). Cloxacillin decreases the number of staphylococci in the mammary gland in a mouse model of acute, but not chronic, mastitis induced by Staphylococcus infection.

Chemical Properties

White Crystalline Powder

Uses

Cloxacillin-13C4 SodiuM Salt is an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lactamase due to its inhibitory effects on beta-lactamase binding.

Purification Methods

Purify cloxacillin sodium salt by dissolving it in isoPrOH containing 20% of H2O, and diluting with isoPrOH to a water content of 5% and chilling. Recrystallise it again in this manner. The sodium salt is collected and dried at 40o in air to give the colourless monohydrate. It is soluble in H2O (5%), MeOH, EtOH, pyridine and ethylene glycol. [Doyle et al. J Chem Soc 5838 1963, Naylor et al. Nature 195 1264 1962.] ( ) -Cocaine {ecogonine methyl ester benzoate, 2 -carbomethoxy-3--benzoxytropane, methyl 1R -(exo,exo)]-3-(benzoyloxy)-2-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate}

Cloxacillin-13C4 SodiuM Salt Preparation Products And Raw materials

Raw materials

6-Aminopenicillanic acid Ethyl acetoacetate

Preparation Products

Sodium cloxacillin monohydrate

Cloxacillin-13C4 SodiuM Salt Suppliers

Global( 247)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Aurobindo Pharma Limited +914066725000 Telangana, India 112 58 Inquiry
Unimark Remedies Ltd +91-2267304120 +91-2267304120 Maharashtra, India 48 58 Inquiry
Penam Laboratories Ltd +91-1145084500 +91-1145084500 New Delhi, India 13 58 Inquiry
Syschem (India) Limited +91-7340783755 +91-8968433155 Haryana, India 8 58 Inquiry
Orient Pharma 91-22-66976686 Maharashtra, India 204 58 Inquiry
Aligns International 91-22-22634745 Maharashtra, India 137 58 Inquiry
Hemlin Chemicals 91-22-25001179 Maharashtra, India 52 58 Inquiry
Cosmos Intenational 91-22-28644685 Maharashtra, India 126 58 Inquiry
Syschem (India) Limited. 91-172-5070471 Haryana, India 3 58 Inquiry
Maas Pharma Chemicals +91-9958666224 Delhi, India 1607 58 Inquiry
Supplier Advantage
Aurobindo Pharma Limited 58
Unimark Remedies Ltd 58
Penam Laboratories Ltd 58
Syschem (India) Limited 58
Orient Pharma 58
Aligns International 58
Hemlin Chemicals 58
Cosmos Intenational 58
Syschem (India) Limited. 58
Maas Pharma Chemicals 58

642-78-4(Cloxacillin-13C4 SodiuM Salt)Related Search:

N,N-Dimethyl-1,4-phenylenediamine Methanol Kresoxim-methyl Methyl acrylate Sodium acetate
Sodium hydroxide Methylparaben Trisodium phosphate Cloxacillin Methyl cellulose
PYRAZOPHOS METSULFURON METHYL Oxacillin sodium monohydrate Bensulfuron methyl Sulfamethoxazole
Fenoxaprop-p-ethyl Chlorodimethylphenylsilane Flucloxacillin sodium
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CLOXACILLIN SODIUM SALT MONOHYDRATE CLOXACILLIN SODIUM SALT N-HYDRATE [5-METHYL-3-(O-CHLOROPHENYL)-4-ISOXAZOLYL]PENICILLIN SODIUM SALT MONOHYDRATE 4-Acetyloxy-N-despropyl Ropivacaine (2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-Methyl-4-isoxazolyl]carbonyl]aMino]-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid SodiuM Salt (2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-Methyl-4-isoxazolyl]carbonyl]aMino]-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid-13C4 SodiuM Salt 3-(o-Chlorophenyl)-5-Methyl-4-isoxazolylpenicillin-13C Cloxacillin-13C4 SodiuM Salt (S)-(-)-Dropropizine-d4 3-dimethyl-7-oxo-thyl-4-isoxazolecarboxamido)-monosodiumsalt 3-o-chlorophenyl-5-methyl-4-isoxazolylpenicillinsodium ankerbin brl-1621sodiumsalt ekvacillin gelstaph monosodiumcloxacillin orbeninsodium prevencilinap prostaphilina 4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-3-(2-chlorophenyl)-5-methyl-4-isoxazolylcarbonylamino-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, [2S-(2α,5α,6β)]- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-, monosodium salt (8CI) Orbenin Sodium 3-(O-chlorophenyl)-5-methyl-4-isoxazolylpenicillin SODIUMCLOXACILLIN(ANHYDROUS) (2S (2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monosodium salt 5R CLOXACILLINSODIUMPOWDER/COMPACTED/STERILELYOPHILED (2S,5R)-6α-[[[3-(2-Chlorophenyl)-5-methylisoxazol-4-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid sodium salt Cloxacillin sodium anhydrous austrastaph prostaphlina sodiumorbenin sodiumsyntarpen staphybiotic syntarpensodiumsalt tegopen Thiazole sodium chloride 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt (1:1), (2S,5R,6R)- sodium 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]-oxomethyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Cloxacillin-13C4 SodiuM Salt USP/EP/BP Cloxacillin-13C4 Sodium SaltQ: What is Cloxacillin-13C4 Sodium Salt Q: What is the CAS Number of Cloxacillin-13C4 Sodium Salt 4S)-Sacubitril 2-Dipalmitoyl-sn-glycero-3-PE 2-Dipalmitoyl-sn-glycerol-3-Phosphoethanolamine 2-DPPE CLOXACILLIN SODIUM SALT HYDRATE cloxapen 3-(o-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin sodium salt Cloxacillin sodium salt Sodium cloxacillin Oxacillin Impurity 5 Sodium Salt (Cloxacillin Sodium Salt) Phenylbutazone Impurity 30 Oxacillin Impurity 17 Sodium Salt 642-78-4 C19H17ClN3NaO5S C19H18ClN3O5SNa