Bacitracin
![Bacitracin Structure](CAS/GIF/1405-87-4.gif)
- CAS No.
- 1405-87-4
- Chemical Name:
- Bacitracin
- Synonyms
- BACITRACIN A;septa;Ziba-RX;baciguent;ayfivin;Agfivin;baci-jel;usafcb-7;BACIDRIN;ALTRACIN
- CBNumber:
- CB9165863
- Molecular Formula:
- C66H102N17O16S
- Molecular Weight:
- 1421.68538
- MOL File:
- 1405-87-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/24 17:31:20
Melting point | 221-225°C |
---|---|
Density | 1.0166 (rough estimate) |
refractive index | 1.6700 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | H2O: 50 mg/mL, clear to very slightly hazy, deep yellow |
form | Powder |
color | white to faintly beige |
Odor | odorless or acetic odor |
Water Solubility | soluble |
Merck | 13,936 |
LogP | -0.050 (est) |
EPA Substance Registry System | Bacitracin (1405-87-4) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H317 |
Precautionary statements | P260-P271-P272-P280g-P302+P352-P304+P340-P312-P363-P403+P233-P501c |
Hazard Codes | Xn |
Risk Statements | 20/21/22 |
Safety Statements | 22-24/25-45-36 |
WGK Germany | 2 |
RTECS | CP0175000 |
F | 21 |
TSCA | Yes |
HS Code | 29419090 |
Toxicity | LD50 oral in guinea pig: 2gm/kg |
Bacitracin price More Price(13)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | B0125 | Bacitracin from Bacillus licheniformis, ≥65?IU/mg | 1405-87-4 | 50000UNITS | ₹3712.98 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | B0125 | Bacitracin from Bacillus licheniformis, ≥65?IU/mg | 1405-87-4 | 250000UNITS | ₹8670.83 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PHR1590 | Bacitracin Pharmaceutical Secondary Standard; Certified Reference Material | 1405-87-4 | 1G | ₹9103.83 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | B0125 | Bacitracin from Bacillus licheniformis, ≥65?IU/mg | 1405-87-4 | 1250000UNITS | ₹24800.08 | 2022-06-14 | Buy |
Sigma-Aldrich | 31626 | Bacitracin A VETRANAL?, analytical standard, main stereoisomer ~50?% | 25MG | ₹6505.83 | 2022-06-14 | Buy |
Bacitracin Chemical Properties,Uses,Production
Description
Bacitracin is a mixture of similar peptides produced by fermentation of the bacterium Bacillus subtil is. The A-type component predominates. Its mode of action is to inhibit both peptidoglycan biosynthesis at a late stage (probably at the dephosphorylation of the phospholipid carrier step) and disruptions of plasma membrane function.
Chemical Properties
Bacitracin is a white to light tan powder which is odorless or having a slight odor and very bitter taste.
Uses
Bacitracin is a peptide antibiotic effective against gram-postive bacteria. Bacitracin is an inhibitor of peptidoglycan synthesis. Bacitracin disrupts bacterial cell wall synthesis by inhibiting depho sphorylation of lipid pyrophosphate. Bacitracin also strongly inhibits proline endopeptidase from human muscle.
Indications
This polypeptide antibiotic, which is produced from Bacillus subtilis,
interferes with bacterial cell wall growth and is bactericidal against many grampositive
organisms such as streptococci, staphylococci, and pneumococci but is
inactive against most gram-negative organisms. All anaerobic cocci, Neisseria, and
the tetanus and diphtheria bacilli are also sensitive to bacitracin.
Resistance is rare,
but some staphylococcal strains are inherently resistant. Hypersensitivity reactions
are uncommon. Bacitracin is stable in petrolatum (but not water-miscible preparations)
and is available as an ointment or as a component of antibiotic mixtures.
Sensitization to bacitracin has been reported more recently, particularly in patients
with leg ulcers.
Definition
A complex of cyclic peptide antibiotic of known chemical structure isolated from the Tracy-I strain of Bacillus subtilis.
Hazard
Poison; moderately toxic; mutagen.
Pharmaceutical Applications
A mixture of peptides produced by Bacillus licheniformis.
Bacitracin A is the major constituent of commercial preparations.
The more stable zinc salt is used in topical formulations.
It has been widely used as a growth promoter in animals, but
has been banned for that purpose in the European Union.
It is highly active against many Gram-positive bacteria
and is mainly used as a component of topical preparations.
Although strains of Staph. aureus are usually susceptible,
they are rather less so than most other Gram-positive bacteria.
Streptococcus pyogenes is so much more susceptible than
other hemolytic streptococci that bacitracin susceptibility is
used as a screening test for identification. Clostridium difficile
and Actinomyces spp. are susceptible, but enterobacteria and
Pseudomonas spp. are resistant. Entamoeba histolytica is inhibited
by 0.6–10 mg/L.
Resistance is uncommon, but has been detected in Staph.
aureus following topical treatment.
It is nephrotoxic and unsuitable for parenteral use. Systemic
toxicity from application to skin or ulcerated areas is rare, but
it may cause allergic reactions and occasional anaphylaxis has
been described. It is found in many ointments and ophthalmic
preparations, usually together with other components,
including polymyxins, neomycin and corticosteroids.
Bacitracin is not absorbed by mouth but oral preparations
have been used for suppression of gut flora, including
C. difficile.
Clinical Use
Bacitracin is predominantly active against Gram-positive microorganisms, and parenteral use is limited to IM injection for infants with pneumonia and empyema caused by staphylococci resistant to other agents. It is rather neuro- and nephrotoxic and, therefore, is used in this manner with caution. Bacitracin also is widely employed topically to prevent infection in minor cuts, scrapes, and burns.
Safety Profile
A poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Mutation data reported.
Potential Exposure
Bacitracin is used as an ingredient in antibiotic ointments to treat or prevent topical or eye infections. Commercial Bacitracin is a mixture of at least 9 bacitracins. Also used as a feed and drinking water additive for animals; as a food additive for human consumption.
Shipping
UN 3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials.
Purification Methods
Bacitracin has been purified by carrier displacement using n-heptanol, n-octanol and n-nonanol as carriers and 50% EtOH in 0.1 N HCl. The pure material gives one spot with RF ~0.5 on paper chromatography using AcOH:n-BuOH:H2O (4:1:5). [Porath Acta Chem Scand 6 1237 1952.] It has also been purified by ion-exchange chromatography. It is a white powder soluble in H2O and EtOH but insoluble in Et2O, CHCl3 and Me2CO. It is stable in acidic solution but unstable in base. It is a strong antibacterial. [Abraham & Bewton Biochem J 47 257 1950, Synthesis: Munekata et al. Bull Chem Soc Jpn 46 3187, 3835 1973, Beilstein 27 III/IV 5746.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste Disposal
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
Bacitracin Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
Otto Chemie Private Limited | 08048372561Ext 825 | Mumbai, India | 76 | 58 | Inquiry |
Innovative | 07942565925 | Mumbai, India | 617 | 58 | Inquiry |
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