Argipressine
- CAS No.
- 113-79-1
- Chemical Name:
- Argipressine
- Synonyms
- ARGININE VASOPRESSIN;argipressin;AVP;ANTIDIURETIC HORMONE;argipressine;Argipression;β-Hypophamine;Arg-Vasopressin;BETA-HYPOPHAMINE;[ARG8]-VASOPRESSIN
- CBNumber:
- CB9205622
- Molecular Formula:
- C46H65N15O12S2
- Molecular Weight:
- 1084.24
- MOL File:
- 113-79-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/28 13:53:27
| Density | 1.59±0.1 g/cm3(Predicted) |
|---|---|
| Flash point | 113℃ |
| storage temp. | 2-8°C |
| pka | 9.90±0.15(Predicted) |
| form | Solid |
| color | White to off-white |
| PH | ~3.5 |
| optical activity | -23.822 (1 mol dm-3 acetic acid) |
| Water Solubility | Water : ≥ 360 mg/mL (332.03 mM) |
| Sequence | H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2，(Disulfide bond) |
| InChIKey | KBZOIRJILGZLEJ-KIIOGHSHNA-N |
Argipressine price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | V9879 | [Arg8]-Vasopressin acetate salt ≥95% (HPLC) | 113-79-1 | 1MG | ₹8779.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V9879 | [Arg8]-Vasopressin acetate salt ≥95% (HPLC) | 113-79-1 | 5MG | ₹31035.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V9879 | [Arg8]-Vasopressin acetate salt ≥95% (HPLC) | 113-79-1 | 25MG | ₹125472.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V0377 | [Arg8]-Vasopressin solution Grade VI (synthetic), ~100?IU/mL in 0.9% NaCl | 113-79-1 | 50IU | ₹9969.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V0377 | [Arg8]-Vasopressin solution Grade VI (synthetic), ~100?IU/mL in 0.9% NaCl | 113-79-1 | 100IU | ₹16843.7 | 2022-06-14 | Buy |
Argipressine Chemical Properties,Uses,Production
Uses
Hormone (antidiuretic).
Definition
ChEBI: The predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.
Indications
ADH (vasopressin) is released primarily in response to increases in plasma osmolarity or decreases in blood volume. It produces its antidiuretic activity in the kidney, causing the cortical and medullary parts of the collecting duct to become more permeable to water, thereby increasing water reabsorption, reducing serum osmolarity, and increasing its volume. It produces this effect by binding to a subset of vasopressin receptors called V2 that have relatively high affinity for the hormone. ADH also has actions at sites other than the kidney. V2 receptors also mediate an increase in circulating levels of two proteins involved in blood coagulation: factor VIII and von Willebrand’s factor.At higher concentrations, ADH interacts with V1 receptors to cause a general constriction of most blood vessels. It also interacts with V3 (or V1b) receptors to increase ACTH release, although the major control of ACTH release occurs through corticotropin-releasing hormone.
General Description
Vasopressin tannate (PitressinTannate) is a water-insoluble tannate of vasopressin administeredintramuscularly (1.5–5.0 pressor units daily)for its prolonged duration of action by the slow release ofvasopressin. It is particularly useful for patients who havediabetes insipidus, but it should never be used intravenously.
Hazard
A poison.
Mechanism of action
ADH itself is available for injections (Pitressin) but has a half-life of about 15 minutes. Desmopressin (DDAVP) is an analogue without an amino group at the first amino acid and with D-arginine instead of Larginine. This analogue is more stable and has very little pressor activity. Desmopressin can be given subcutaneously or nasally, and the effects last for 12 hours.
Clinical Use
Because it is stable, desmopressin is preferred for
treatments especially if pressor effects are not desired.
The primary indication for therapy is central diabetes
insipidus, a disorder that results when ADH secretion is
reduced and that is characterized by polydipsia,
polyuria, and dehydration. Desmopressin is also used to
reduce primary nocturnal enuresis, or bedwetting, in
children. It is useful in people with mild hemophilia A
or with some types of von Willebrand’s disease, in which
von Willebrand’s factor is present at low levels. In these
cases, desmopressin is given when excessive bleeding
occurs or before surgery to help reduce bleeding indirectly
by increasing the amounts of coagulation factors.
A possible adverse effect of desmopressin is water intoxication
if too much is taken.
ADH antagonists, including nonpeptide analogues
that may be taken orally, have been developed with
specificity for each of the receptor types. In the future,
those that block V1 receptors may be useful in treating
hypertension, and those that block V2 receptors may be
useful in any condition of excessive water retention or
hyponatremia, for which so far there is no satisfactory
therapeutic treatment.
Safety Profile
A poison by intravenous route.When heated to decomposition it emits toxic vapors ofNOx and SOx.
Argipressine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Piramal Pharma Solutions | +919892735994 | Maharashtra, India | 48 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 50003 | 58 | Inquiry |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | China | 2944 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12585 | 58 | Inquiry |
| Shanghai Yunao International Trade Co., Ltd | +8617621705551 | China | 265 | 58 | Inquiry |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | China | 2503 | 58 | Inquiry |
| qingdao future trading Co., Ltd | +86-13335044410 +86-13335044410 | China | 110 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10991 | 58 | Inquiry |
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