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Mezlocillin

Mezlocillin Structure
CAS No.
51481-65-3
Chemical Name:
Mezlocillin
Synonyms
Melocin;Bay-f 1353;Multocillin;MEZLOCILLIN;Meslocillin;Meloxacam acid;Mezlocillin acid;Melocillin sodium;Meloxicillin acid;antibioticbay-f1353
CBNumber:
CB9268151
Molecular Formula:
C21H25N5O8S2
Molecular Weight:
539.58
MOL File:
51481-65-3.mol
MSDS File:
SDS
Modify Date:
2024/4/22 13:56:47
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Mezlocillin Properties

Density 1.63±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka pKa 2.7 (Uncertain)
CAS DataBase Reference 51481-65-3(CAS DataBase Reference)

Mezlocillin Chemical Properties,Uses,Production

Description

Mezlocilin is an acylaminopenicillin, which has been shown to cause both immediate and delayed hypersensitivity in a nurse.

Uses

Like azlocillin, mezlocillin is used for infections of the urinary tract, gynecological infections, intraabdominal infections, skin infections, and respiratory tract infections. Synonyms of this drug are baypen, mezlin, and optocillin.

Definition

ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a (2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido group.

Antimicrobial activity

A semisynthetic acylureidopenicillin supplied as the sodium salt for parenteral administration.
Ampicillin-susceptible strains of H. influenzae and Neisseria spp. are very susceptible, but β-lactamase-producing organisms are usually resistant. It is less active than azlocillin and piperacillin against Ps. aeruginosa and has variable activity against B. fragilis, independent of β-lactamase production. It exhibits typical β-lactam synergy with aminoglycosides against Ps. aeruginosa and enterobacteria.
It attains peak concentrations of 250 mg/L after a 2 g intravenous infusion, with a plasma half-life of 55 min. Protein binding is 20–30%. It distributes into multiple tissues and human body fluids at therapeutically useful concentrations. Up to 60% of the dose is recoverable unchanged from the urine, with up to 2.5% excreted in the bile.
Toxicity and side effects are similar to those associated with carboxypenicillins. Its clinical use is for serious infections with susceptible organisms, including lower respiratory tract, intra-abdominal, urinary tract and gynecological infections. Commercial availability is quite limited.

General Description

Mezlocillin was synthesized by Bayer in 1974. The NH2 residue of ampicillin was acylated. Mezlocillin is a member of the so-called ureidopenicillins and shows two- to eightfold greater activity against Citrobacter, Enterobacter, Klebsiella, Escherichia coli, and Haemophilus influenzae than ampicillin, carbenicillin, or sulbenicillin. Its activity against gram-positive bacteria is almost the same as that of carbenicillin. Mezlocillin is used by intravenous administration for therapy of sepsis, meningitis, and respiratory tract, urinary tract, and abdominal infections.

Mezlocillin Preparation Products And Raw materials

Raw materials

PHOSGENE Methanesulfonyl chloride 2-Imidazolidone Ampicillin 3-Chlorocarbonyl-1-methanesulfonyl-2-imidazolidinone

Preparation Products

Mezlocillin Suppliers

Global( 135)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
Hebei Mojin Biotechnology Co., Ltd +8613288715578 China 12458 58 Inquiry
Ouhuang Engineering Materials (Hubei) Co., Ltd +86-86177 China 2901 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21669 55 Inquiry
Hebei Guanlang Biotechnology Co., Ltd. +86-19930503282 China 8826 58 Inquiry
Xiamen AmoyChem Co., Ltd +86-592-6051114 +8618959220845 China 6387 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
SIMAGCHEM CORP +86-13806087780 China 17367 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418671 China 34571 58 Inquiry
Supplier Advantage
CHEMSWORTH 30
Hebei Mojin Biotechnology Co., Ltd 58
Ouhuang Engineering Materials (Hubei) Co., Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55
Hebei Guanlang Biotechnology Co., Ltd. 58
Xiamen AmoyChem Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
SIMAGCHEM CORP 58
Hefei TNJ Chemical Industry Co.,Ltd. 58

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(2s-(2-alpha,5-alpha,6-beta)(s*))-sodiumsal 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-6-(((((3-(met antibioticbay-f1353 3,3-dimethyl-7-[[2-[(3-methylsulfonyl-2-oxo-imidazolidin-1-yl)carbonylamino]-2-phenyl-acetyl]amino]-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylic acid Melocillin sodium Meloxacam acid Mezlocillin acid MEZLOCILLIN SODIUM USP(CRM STANDARD) 6α-[[(R)-[[[3-(Methylsulfonyl)-2-oxoimidazolidin-1-yl]carbonyl]amino]phenylacetyl]amino]penicillanic acid Multocillin Mezlocillin(Mezlocillin sodium) MEZLOCILLIN Mezlocillin Solution, 100ppm (2S,5R,6R)-3,3-dimethyl-6-[[(2R)-2-[[(3-methylsulfonyl-2-oxo-1-imidazolidinyl)-oxomethyl]amino]-1-oxo-2-phenylethyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-6-[[(2R)-2-[[[3-(methylsulfonyl)-2-oxo-1-imidazolidinyl]carbonyl]amino]-2-phenylacetyl]amino]-7-oxo-, (2S,5R,6R)- Mezlocillin USP/EP/BP Meloxicillin acid Bay-f 1353 Melocin Meslocillin (2S,5R,6R)-3,3-Dimethyl-6-((R)-2-(3-(methylsulfonyl)-2-oxoimidazolidine-1-carboxamido)-2-phenylacetamido)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 51481-65-3 51484-65-3