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Mezlocillin sodium

Mezlocillin sodium Structure
CAS No.
59798-30-0
Chemical Name:
Mezlocillin sodium
Synonyms
Chebi:52067;MEZLOCILLIN SODIUM;Mezlocillin　Baypen;Meloxicillin sodium;Sodium salt monohydrate;Mezlocillin (sodium salt);Mezlocillin Sodium (350 mg);Mezlocillin sodium USP/EP/BP;Sodium 6beta-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanate;Sodium 6beta-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}-2,2-dimethylpenam-3alpha-carboxylate
CBNumber:
CB4353793
Molecular Formula:
C22H27N6NaO9S2
Molecular Weight:
606.6
MOL File:
59798-30-0.mol
Modify Date:
2024/4/29 22:41:02
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Mezlocillin sodium Properties

Melting point 197-201°C (dec.)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
Water Solubility Soluble in water or DMSO
CAS DataBase Reference 59798-30-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H334
Precautionary statements  P261-P285-P304+P341-P342+P311-P501

Mezlocillin sodium Chemical Properties,Uses,Production

Description

Mezlocillin is a β-lactam antibiotic and derivative of ampicillin . It is active against B. fragilis, E. lentum, P. morbillorum, and F. nucleatum (MICs = 8, 4, 2, and 4 μg/ml, respectively). Mezlocillin (32 μg/ml) is also active against 10 strains of S. faecalis. In vivo, mezlocillin (240 mg/kg) increases survival and reduces bacteremia in a rabbit model of S. faecalis endocarditis. It completely eliminates lung P. morbillorum, E. lentum, and F. nucelatum, but not B. fragilis, in a rabbit model of pulmonary P. morbillorum, E. lentum, F. nucelatum, and B. fragilis infection when administered at a dose of 300 mg/kg. Formulations containing mezlocillin have been used in the treatment of various bacterial infections.

Chemical Properties

Mezlocillin sodium is white to slightly yellow cryst. powder

Uses

Mezlocillin Sodium (cas# 59798-30-0) is a derivative of penicillin and an antimicrobial.

Clinical Use

Mezlocillin (Mezlin) is an acylureidopenicillin with an antibacterialspectrum similar to that of carbenicillin andticarcillin; however, there are some major differences. It ismuch more active against most Klebsiella spp., P. aeruginosa,anaerobic bacteria (e.g., Streptococcus faecalis andB. fragilis), and H. influenzae. It is recommended for thetreatment of serious infections caused by these organisms.
Mezlocillin is not generally effective against β-lactamase–producing bacteria, nor is it active orally. It isavailable as a white, crystalline, water-soluble sodium saltfor injection. Solutions should be prepared freshly and, ifnot used within 24 hours, refrigerated. Mezlocillin and otheracylureidopenicillins, unlike carbenicillin, exhibit nonlinearpharmacokinetics. Peak plasma levels, half-life, and areaunder the time curve increase with increased dosage.Mezlocillin has less effect on bleeding time than carbenicillin,and it is less likely to cause hypokalemia.

Mezlocillin sodium Preparation Products And Raw materials

Raw materials

Preparation Products

Mezlocillin sodium Suppliers

Global( 183)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
OCEAN TRADING CORPORATION +91(22) 24921669 New Delhi, India 6211 58 Inquiry
Hebei Mojin Biotechnology Co., Ltd +86 13288715578 +8613288715578 China 12459 58 Inquiry
Shaanxi TNJONE Pharmaceutical Co., Ltd +8618740459177 China 1142 58 Inquiry
Ouhuang Engineering Materials (Hubei) Co., Ltd +86-86177 China 2952 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Hebei Guanlang Biotechnology Co., Ltd. +86-19930503282 China 8828 58 Inquiry
Xiamen AmoyChem Co., Ltd +86-592-6051114 +8618959220845 China 6387 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
SIMAGCHEM CORP +86-13806087780 China 17367 58 Inquiry
Supplier Advantage
OCEAN TRADING CORPORATION 58
Hebei Mojin Biotechnology Co., Ltd 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 58
Ouhuang Engineering Materials (Hubei) Co., Ltd 58
career henan chemical co 58
Hebei Guanlang Biotechnology Co., Ltd. 58
Xiamen AmoyChem Co., Ltd 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
SIMAGCHEM CORP 58

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(2S,5R,6R)-3,3-DiMethyl-6-((R)-2-(3-(3-(Methylsulfonyl)-2-oxoiMidazolidine-1-carbonyl)ureido)-2-phenylacetaMido)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, sodiuM salt Chebi:52067 Sodium (2S,5R,6R)-3,3-dimethyl-6-{[(2R)-2-({[3-(methylsulfonyl)-2-oxoimidazolidin-1-yl]carbonyl}amino)-2-phenylacetyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Sodium 6beta-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}-2,2-dimethylpenam-3alpha-carboxylate Sodium 6beta-{(2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanate Mezlocillin Sodium (350 mg) 3,3-dimethyl-6-[[2-[(3-methylsulfonyl-2-oxo-imidazolidin-1-yl)carbonylamino]-2-phenyl-acetyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt MEZLOCILLIN SODIUM Sodium salt monohydrate sodium 3,3-dimethyl-6-[[2-[[(3-methylsulfonyl-2-oxo-1-imidazolidinyl)-oxomethyl]amino]-1-oxo-2-phenylethyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Mezlocillin　Baypen Mezlocillin (sodium salt) Mezlocillin sodium USP/EP/BP Meloxicillin sodium 59798-30-0 C21H24N5NaO8S2 C21H24N5O8S2NaH2O C21H24NaN5O8S2H2O Miscellaneous