Fosfomycin tromethamine
- CAS No.
- 78964-85-9
- Chemical Name:
- Fosfomycin tromethamine
- Synonyms
- FOSFOMYCIN TROMETAMOL;FOSFOMYCIN TROMETHAMOL;phosphomycin trometamol;tromethamine-fosfomycin;z1282;monuril;Fosfomycin tromethanol;fosfomycin tromethamine;fosfomycintrometamolsalt;Tromethamine fosfosmycin
- CBNumber:
- CB9365184
- Molecular Formula:
- C7H18NO7P
- Molecular Weight:
- 259.19
- MOL File:
- 78964-85-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/8 17:36:13
| Melting point | 122-125oC |
|---|---|
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone. |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| InChIKey | QZJIMDIBFFHQDW-LMLSDSMGSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H319-H317-H334-H315 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| HS Code | 2941906000 |
Fosfomycin tromethamine Chemical Properties,Uses,Production
Chemical Properties
White to off-white powder
Uses
Fosfomycin Tromethamine is used as an antibiotic compound in the treatment of urinary tract infections.
General Description
Fosfomycin tromethamine (Monurol) is a phosphonic acidepoxide derivative that was initially isolated from fermentationsof Streptomyces spp. Making the tromethamine salt greatly expanded the therapeutic utility of this antibacterial because water solubilityincreased enough to allow oral administration.
Fosfomycin is a broad-spectrum, bactericidal antibacterialthat inhibits the growth of E. coli, S. aureus, andSerratia, Klebsiella, Citrobacter, Enterococcus, andEnterobacter spp. at a concentration less than 64 mg/L.Currently fosfomycin is recommended as single-dose therapyfor uncomplicated urinary tract infections. It possessesin vitro efficacy similar to that of norfloxacin and trimethoprim-sulfamethoxazole.
Fosfomycin covalently inactivates the first enzyme in thebacterial cell wall biosynthesis pathway, UDP-N-acetylglucosamineenolpyruvyl transferase (MurA) by alkylation ofthe cysteine-115 residue. The inactivation reaction occursthrough nucleophilic opening of the epoxide ring. Resistanceto fosfomycin can occur through chromosomal mutationsthat result in reduced uptake or reduced MurA affinity for theinhibitor. Plasmid-mediated resistance mechanisms involveconjugative bioinactivation of the antibiotic with glutathione.The frequency of resistant mutants in in vitro studies hasbeen low, and there appears to be little cross-resistance betweenfosfomycin and other antibacterials.
Fosfomycin tromethamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Bajaj Healthcare Ltd | +91-2266177400 +91-2266177400 | Maharashtra, India | 86 | 58 | Inquiry |
| Sumar Biotech LLP | +91-7984183709 +91-9824575381 | Gujarat, India | 22 | 58 | Inquiry |
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| Molsyns Research | +91-9586858886 +91-9586858886 | Gujarat, India | 418 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| KARPSCHEM LABORATORIES | 58 |
| Bajaj Healthcare Ltd | 58 |
| Sumar Biotech LLP | 58 |
| BDR Pharmaceuticals International Pvt Ltd | 58 |
| Molsyns Research | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| SynZeal Research Pvt Ltd | 58 |
| Pharma Affiliates | 58 |
| Triveni chemicals | 58 |
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