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Fosfomycin

Fosfomycin Structure
CAS No.
23155-02-4
Chemical Name:
Fosfomycin
Synonyms
FOM;PHOSPHOMYCIN;883a;mk-955;C06454;MK 0955;fosfocina;Fosfomicin;FOSFOMYCIN;Isoramycin
CBNumber:
CB7446605
Molecular Formula:
C3H7O4P
Molecular Weight:
138.06
MOL File:
23155-02-4.mol
Modify Date:
2024/3/19 15:37:50
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Fosfomycin Properties

Melting point 94°C
Boiling point 342.7±52.0 °C(Predicted)
Density 1.56±0.1 g/cm3(Predicted)
pka 3.20±0.40(Predicted)
form solid
CAS DataBase Reference 23155-02-4(CAS DataBase Reference)

Fosfomycin Chemical Properties,Uses,Production

Chemical Properties

Water-soluble crystals.

Uses

Antibacterial.

Definition

ChEBI: A phosphonic acid having an (R,S)-1,2-epoxypropyl group attached to phosphorus.

Biological Activity

Fosfomycin shows antibacterial activity against gram-positive and gram-negative organisms, including Pseudomonas aeruginosa andSerratiamarcescens,andβ-lactam-resistant Staphylococcus aureus. Its mechanism of action is probably the inhibition of cell-wall synthesis. It shows no cross-resistance with other classes of antibiotics.

Biological Activity

Fosfomycin shows antibacterial ac tivity against gram-positive and gram-negative organisms, including Pseudomonas aeruginosa andSerratiamarcescens,andβ-lactam-resistant Staphylococcus aureus. Its mechanism of action is probably the inhibition of cell-wall synthesis. It shows no cross-resistance with other classes of antibiotics.

Clinical Use

Phosphomycin, introduced in 1972, inhibits enolpyruvial transferase, an enzyme catalyzing an early step in bacterial cell wall biosynthesis. Inhibition results in reduced synthesis of peptidoglycan, an important component in the bacterial cell wall. Phosphomycin is bactericidal against Escherichi a coli and Enterobacter faecali s infections.

structure and hydrogen bonding

Fosfomycin's chemical structure is simple anduniqueamongantibiotics inhavinga C–P bond.

Fosfomycin Preparation Products And Raw materials

Raw materials

A-phenethylamine Sodium Phosphate, Dibasic Propargyl alcohol Acetophenone Phosphorus trichloride
Acetaldehyde tert-Butyl Hypochlorite ZINC-COPPER COUPLE HYDROXYMETHYL PHOSPHONIC ACID
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Preparation Products

Tobramycin

Fosfomycin Suppliers

Global( 114)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Venkatasai Life Sciences +91-9908134868 +91-8008303069 Hyderabad, India 186 58 Inquiry
PROTECH TELELINKS +91-8571891912 +91-9855060837 Himachal Pradesh, India 62 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Triveni chemicals 08048762458 New Delhi, India 6093 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Hebei Yanxi Chemical Co., Ltd. +86-17531190177; +8617531190177 China 6011 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21678 55 Inquiry
career henan chemical co +86-0371-86658258 15093356674; China 29826 58 Inquiry
Supplier Advantage
Venkatasai Life Sciences 58
PROTECH TELELINKS 58
SynZeal Research Pvt Ltd 58
Pharma Affiliates 58
Triveni chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
CLEARSYNTH LABS LTD. 58
Hebei Yanxi Chemical Co., Ltd. 58
Henan Tianfu Chemical Co.,Ltd. 55
career henan chemical co 58

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23155-02-4(Fosfomycin)Related Search:

Zoledronic acid 1-Hydroxyethylidene-1,1-diphosphonic acid Citric acid Folic acid Disodium pamidronate
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fosfocina fosfonomycin mk-955 FOSFOMYCIN Fosfomycin (base and/or unspecified salts) (3-Methyloxiran-2-yl)phosphonic acid Phosphonic acid, (2R,3S)-3-methyloxiranyl- (-)-(cis-1,2-Epoxypropyl)phosphonic acid Fosfomicin MK 0955 Phosphonic acid, (1,2-epoxypropyl)-, (1R,2S)-(-)- (8CI) Phosphonic acid, (3-methyloxiranyl)-, (2R-cis)- FOSFORMYCIN [(2R,3S)-3-Methyloxirane-2-yl]phosphonic acid Isoramycin C06454 ((2R,3S)-3-Methyloxiran-2-yl)phosphonic acid Phosphonicacid, P-[(2R,3S)-3-Methyl-2-oxiranyl]- Phosphonomycin (1,2-epoxypropyl)-,(1r,2s)-(-)-phosphonicaci (2r-cis)-(3-methyloxiranyl)phosphonicacid (2r-cis)-phosphonicaci (3-Methyloxiranyl)phosphonicacid 883a antibiotic833a Fosfomycin(Sodium salt form) Fosfomycin USP/EP/BP Fosfomycin Sodium DISCONTINUED, offer F727505 or F727500 PHOSPHOMYCIN FOM 1,2-epoxypropyl phosphonicaci Eicosapentaenoic Acid Impurity 45 Fosfomycin iMpurity 23155-02-4 Antibiotics A to Z Antibiotics BioChemical Antibiotics N-S Antibiotics