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4-Amino-5-aminomethyl-2-methylpyrimidine

CAS No.: 95-02-3

Chemical Name:: 4-Amino-5-aminomethyl-2-methylpyrimidine

Synonyms: Grewe DiaMine;2-methyl-4-amino-5-aminomethylpyrimidine;4-amino-2-methylpyrimidine-5-methylamine;Thiamine Impurity 16;Thiamine Impurity 48;Diazinon Impurity 6 (Diazoxon);Thiamine /Vitamin B1 Impurity 19;2-Methyl-4-aminopyrimidine-5-methanamine;5-Aminomethyl-2-methyl-4-pyrimidineamine;4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE

CBNumber:: CB9757404

Molecular Formula:: C6H10N4

Molecular Weight:: 138.17

MOL File:: 95-02-3.mol

Modify Date:: 2024/1/18 17:03:05

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4-Amino-5-aminomethyl-2-methylpyrimidine Properties

Melting point	270-272°C
Boiling point	121-125 °C
Density	1.207
vapor pressure	0.012-0.019Pa at 20-25℃
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
form	Solid
pka	7.70±0.29(Predicted)
color	Off-White to Beige
PH	10.65 at 20℃ and 10g/L
InChI	InChI=1S/C6H10N4/c1-4-9-3-5(2-7)6(8)10-4/h3H,2,7H2,1H3,(H2,8,9,10)
InChIKey	OZOHTVFCSKFMLL-UHFFFAOYSA-N
SMILES	C1(C)=NC=C(CN)C(N)=N1
LogP	-2.27 at 20℃ and pH7
Surface tension	72.77mN/m at 1g/L and 20℃

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P280-P305+P351+P338-P310
HS Code	2933599590

4-Amino-5-aminomethyl-2-methylpyrimidine price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemicals (India)	A2633	4-Amino-5-aminomethyl-2-methylpyrimidine	95-02-3	200MG	₹20900	2022-05-26	Buy

Product number	Packaging	Price	Buy
A2633	200MG	₹20900	Buy

4-Amino-5-aminomethyl-2-methylpyrimidine Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Substrate for TenA enzyme in the thiamin salvage pathway

Definition

ChEBI: An aminopyrimidine compound having its amino substituent at the 4-position together with methyl and aminomethyl substituents at the 2- and 5-positions respectively.

Synthesis

In an autoclave, the mixture of 4-Amino-5-aminomethyl-2-methylpyrimidine (2.0 kg, 15 mol), modified Raney nickel (wet weight 300 g), and saturated methanol solution of ammonia (20 L) was heated to 100 ℃ and stirred for 5 h at this temperature under 4 MPa hydrogen pressure. Then, the mixture was cooled to room temperature and filtered; 4-Amino-5-aminomethyl-2-methyl pyrimidine was obtained as a white solid (2.0 kg, 98%) by concentrating the filtrate[1].

References

[1] Lei Zhao, Fen-Er Chen, Xiao-Dong Ma. “Development of Two Scalable Syntheses of 4-Amino-5-aminomethyl-2-methylpyrimidine: Key Intermediate for Vitamin B1.” Organic Process Research & Development 16 1 (2011): 57–60.

4-Amino-5-aminomethyl-2-methylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

THIAMINE HYDROCHLORIDE

4-Amino-5-aminomethyl-2-methylpyrimidine Suppliers

Global( 84)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Changzhou uniringchem Co., Ltd.	+undefined13585446801	China	68	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21675	55	Inquiry
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	CHINA	21149	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	China	34571	58	Inquiry
Blocksynth Pharmaceutical Technology Co.,Ltd	0086-19817745290; +8619817745290	China	5660	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	26165	58	Inquiry
Finetech Industry Limited	+86-27-87465837 +8618971612321	China	9626	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
TCI Chemicals (India) Pvt. Ltd.	58
Changzhou uniringchem Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Blocksynth Pharmaceutical Technology Co.,Ltd	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58

95-02-3(4-Amino-5-aminomethyl-2-methylpyrimidine )Related Search:

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Amprolium 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium dodecyl sulfate 5-PYRIMIDINEMETHANAMINE 2-Methylpyrimidine HYDROXYETHYLTHIAMINE HYDROCHLORIDE

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4-Amino-2-methyl-5-pyrimidinemethanamine,dihydrochlorine 2-Methyl-4-aminopyrimidine-5-methanamine 2-Methyl-5-(aminomethyl)-4-pyrimidinamine 5-Aminomethyl-2-methyl-4-pyrimidineamine (4-amino-2-methyl-pyrimidin-5-yl)methylamine 4-AMINO-2-METHYL-5-PYRIMIDINEMETHANAMINE, DIHYDROCHLORIDE 4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE, DIHYDROCHLORIDE 5-Pyrimidinemethanamine, 4-amino-2-methyl- (9CI) 5-(Aminomethyl)-4-amino-2-methylpyrimidine 5-PyriMidineMethanaMine,4-aMino-2-Methyl- 4-Amino-5-aminomethyl-2-methylpyrimidine hydrochloride 2-methyl-4-amino-5-aminomethylpyrimidine 2HCl Thiamine Impurity 16 4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE, DIHYDROCHLORIDE ISO 9001：2015 REACH 2-methyl-4-amino-5-aminomethylpyrimidine Grewe DiaMine 4-amino-2-methylpyrimidine-5-methylamine Thiamine Impurity 48 Diazinon Impurity 6 (Diazoxon) 4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE Thiamine /Vitamin B1 Impurity 19 95-02-3 C6H12Cl2N4 C6H10N42HCl Bases & Related Reagents Nucleotides Amines Aromatics Enzyme substrates Heterocycles Nucleotides and Nucleosides Heterocycle-Pyrimidine series PYRIMIDINE