ChemicalBook > Product Catalog >API >Circulatory system drugs >Antihypertensive drugs >3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

CAS No.: 86499-96-9

Chemical Name:: 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

Synonyms: 3-BroMo-2;IHT-PI BBC;3-Bromo-2,3,4,5-tetr;3-bromobenzocaprolactam;A-BROMOBENZOCAPROLACTAM;α-Bromobenzocaprolactam;ALPHA-BROMOBENZO-CAPROLACTAM;3-Bromo-2,3,4,5-tetrahydro-2H-;3-BromoTetrahydrobenazepin-2-One;5-Trtrahydro-2H-1-benzazepine-2-one

CBNumber:: CB9777910

Molecular Formula:: C10H10BrNO

Molecular Weight:: 240.1

MOL File:: 86499-96-9.mol

MSDS File:: SDS

Modify Date:: 2024/4/16 14:59:45

Request For Quotation

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Properties

Melting point	164 °C
Boiling point	383.2±42.0 °C(Predicted)
Density	1.492±0.06 g/cm3(Predicted)
Flash point	185.542℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	slightly soluble in ethanol, benzene, acetone, insoluble in water
pka	13.59±0.40(Predicted)
CAS DataBase Reference	86499-96-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Chemical Properties,Uses,Production

Uses

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one is an intermediate in the synthesis of Benazepril Hydrochloride. Benazepril Hydrochloride is a first-line antihypertensive drug recommended by the WHO. It is a chiral drug with excellent clinical efficacy, strong safety and tiny side effects in the international antihypertensive drugs of angiotensin converting enzyme inhibitors.

Chemical Properties

White or almost white crystalline

Preparation

The preparation of 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one is as follows:10 parts by weight of the heated melted polyphosphoric acid was added to the drying kettle, With stirring, The above 2-bromo-3,4-dihydro-N-hydroxy- (2H) -naphthalimide was added in portions at a temperature of 60 ° C, Insulation reaction for 20 hours; The reaction solution was added dropwise to 12.5 parts by weight of water to carry out hydrolysis, Still Washed to give 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one crude; 10 parts by weight of methanol and 0.1 part by weight of activated carbon were added, Heating decolorization, After filtration, the filtrate was cooled to 10 ° C for 20 hours, centrifuged, washed and dried to give 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepan-2-one. The purity of the product was 3, 10-bromo-1,3,4,5-tetrahydro-2H-1-benzazepan-2-one as high as 99.6% and the yield was as high as 98%.

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Preparation Products And Raw materials

Raw materials

1(2H)-Naphthalenone, 2-bromo-3,4-dihydro-, oxime 2-Bromo-1,2,3,4-tetrahydronaphthalen-1-one 1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one Benzene 1-Tetralone

Preparation Products

L-Homophenylalanine ethyl ester S-ATBA [S-(R*,R*)]-1,3,4,5-Tetrahydro-3-[(1-phenylethyl)amino]-2H-1-benzazepin-2-one

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Suppliers

Global( 299)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
INTEGRAL BIO SCIENCES	+91-1204663222 +91-9177003936	New Delhi, India	9	58	Inquiry
GSV speciality chemicals	+91-91823634932 +91-91823634932	Hyderabad, India	127	58	Inquiry
Suposha Life Sciences	+91 73308 95313	Telangana, India	32	58	Inquiry
VGS SYNTHESIS PRIVATE LIMITED	+91-9866975588 +91-9866975588	Hyderabad, India	1818	58	Inquiry
Mekong pharmaceuticals pvt ltd	+91-4035163894 +91-8008212221	Telangana, India	129	58	Inquiry
Parth Antibiotics Pvt Ltd.	+91 (22) 2562-8329	New Delhi, India	173	50	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
AstaTech(Chengdu) Biopharmaceutical Corp.	+86-02882666559 +86-15884417729	China	308	58	Inquiry

Supplier	Advantage
INTEGRAL BIO SCIENCES	58
GSV speciality chemicals	58
Suposha Life Sciences	58
VGS SYNTHESIS PRIVATE LIMITED	58
Mekong pharmaceuticals pvt ltd	58
Parth Antibiotics Pvt Ltd.	50
TCI Chemicals (India) Pvt. Ltd.	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
AstaTech(Chengdu) Biopharmaceutical Corp.	58

86499-96-9(3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one)Related Search:

Benzo[b]thien-2-ylboronic acid 2-Bromoethylamine hydrobromide Tetrahydro-4H-pyran-4-one 3-Bromoanisole N-Methyl-2-pyrrolidone

Epiandrosterone acetate 4'-Bromoacetophenone 2-Bromoacetophenone Laurocapram Dehydroepiandrosterone

Phosphorus oxybromide Bromine 1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one 2-bromo-N-(o-tolyl)propionamide 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

Nitrogen and hydrogen mixed gas Tetrahydro

chevron_left

1of4

chevron_right

A-BROMOBENZOCAPROLACTAM ALPHA-BROMOBENZO-CAPROLACTAM 3-Bromobenzocaprolactam 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 3-bromobenzocaprolactam 3-bromo-1,3,4,5-tetrahdro-2h-benzazepin-2-one 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPINE-2-ONE 3-BROMO-1,3,4,5-TETRAHYDRO-2H-L-BENZAZEPIN-2-ONE 3-BROMO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 3-BROMO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE-2-ONE 3-BROMO-2,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE 3-BROMO-2,3,4,5-TETRAHYDRO-2H-BENZO[B]AZEPIN-2-ONE 3-BROMO-2,3,4,5-TETRAHYDRO-2-OXO-1H-1-BENZAZEPINE 3-BROMO-2,3,4,5-TRTRAHYDRO-2H-1-BENZAZEPINE-2-ONE 3-BROMO-1,3,4,5-TETRAHYDRO-2H-BENZAZEPIN-2-ONE 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAEPINE-2-ONE 3-BBC: 3-BROMO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPIN-2-ONE 3-BROMO-2,3,4,5-TETRAHYDRO-2H-1-BENZAZEPINE-2-ONE 3-Bromo-2,3,4,5-tetrahydro-2H- 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPINE-2-ONE HPLC +99.0% 3-BromoTetrahydrobenazepin-2-One 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE (3-BROMO LACTAM) α-Bromobenzocaprolactam 3-bromo-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one IHT-PI BBC 3-Bromo-2,3,4,5-tetr 3-BroMo-2 5-Trtrahydro-2H-1-benzazepine-2-one 2H-1-Benzazepin-2-one, 3-broMo-1,3,4,5-tetrahydro- Intermediate 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 3-bromo-1,3,4,5-tetrahydro-2H-1-benzoazepine-2-one 3-bromo-1,3,4,5-tetrahydro-1-benzazepin-2-one 3-bromo-1,3,4,5-tetrahydro-2H-1-benzoazepine-2-on 5-tetrahydro-2H-benzo[b]azepin-2-one 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one > 3-Bromo-2,3,4,5-tetrahydro-2-h-1-benzacepin–2one 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one USP/EP/BP 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one (Benazepril API KSM) 3-Bromo-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one (Alpha-Bromolactum) 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzoazo-2-one 3-Bromo-1,3,4,5-tetrahydro-2-h-1-benzacepin–2one 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one / Benazepril intermediate 86499-96-9 65-71-6 68499-96-9 96499-96-9 C10H10BrNO C10H10NOBr pharmacetical 86499-96-9 john's