세르마글루타이드
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세르마글루타이드 속성
- 저장 조건
- Store at -20°C
- 용해도
- DMSO:3mg/mL (0.73 mM)
- 물리적 상태
- Solid
- 색상
- White to off-white
- InChIKey
- DLSWIYLPEUIQAV-CCUURXOWSA-N
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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신호 어: | Warning | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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세르마글루타이드 C화학적 특성, 용도, 생산
개요
Semaglutide(910463-68-2) is an anti-diabetic medication that is sold under brand names such as Ozempic, Wegovy, and Rybelsus. It is used to treat type 2 diabetes and manage chronic weight. The drug functions similar to human glucagon-like peptide-1 (GLP-1) by increasing insulin secretion, which leads to improved sugar metabolism. It is distributed as a metered subcutaneous injection in a prefilled pen, or as an oral form. One of its advantages over other antidiabetic drugs is that it has a long duration of action, thus, only once-a-week injection is sufficient.용도
Semaglutide is used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity. It also works by slowing the movement of food through the stomach and may decrease appetite and cause weight loss. There have been no published reports of hepatotoxicity attributed to semaglutide therapy.Mechanism of action
Semaglutide is a glucagon-like peptide-1 receptor agonist. It increases the production of insulin, a hormone that lowers the blood sugar level. It also appears to enhance growth of β cells in the pancreas, which are the sites of insulin production. It also inhibits glucagon, which is a hormone that increases blood sugar. It additionally reduces food intake by lowering appetite and slows down digestion in the stomach. In this way it reduces body fat.Pharmacokinetics
Median tmax,semaglutide was 1.5 hours for both water volumes with a range of 0.5-3.0 hours for 50 mL and a range of 0.5-4.0 hours for 240 mL. AUC0-24h,semaglutide and Cmax,semaglutide were approximately 70% higher when dosed with 50 versus 240 mL water[2].부작용
Some common side effects of Semaglutide include: nausea, vomiting, diarrhea, abdominal pain, and constipation may occur.Less common but serious side effects of Semaglutide include: kidney problems, diabetic retinopathy, allergic reactions, low blood sugar, and pancreatitis.
In people with heart problems, it can cause damage to the back of the eye (retinopathy). If you experience any of these serious side effects, contact your healthcare provider immediately.
www.mayoclinic.org
신진 대사
Intact semaglutide was the primary component circulating in plasma for humans and both nonclinical species, accounting for 69–83% of the total amount of semaglutide-related material, and was metabolised prior to excretion. Recovery of excreted radioactivity was 75.1% in humans, 72.1% in rats and 58.2% in monkeys. Urine and faeces were shown to be important routes of excretion, with urine as the primary route in both humans and animals[1]. Semaglutide was metabolised through proteolytic cleavage of the peptide backbone and sequential beta-oxidation of the fatty acid sidechain, and metabolism was not confined to specific organs. Intact semaglutide in urine accounted for 3.1% of the administered dose in humans and less than 1% in rats; it was not detected in urine in monkeys.주의 사항
The FDA recommends Wegovy for weight loss if you meet one of the following criteria: Have a body mass index (BMI) of 27kg/m2 or greater and at least one weight-related condition, such as high blood pressure, Type 2 diabetes, or high cholesterol; Have a BMI of 30kg/m2 or greater.Avoid semaglutide if you have: History of medullary thyroid cancer; History of gallbladder disease; History of pancreatitis; Multiple endocrine neoplasia syndrome type 2 (MEN2).
세르마글루타이드 준비 용품 및 원자재
원자재
준비 용품
세르마글루타이드 공급 업체
글로벌( 472)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Hubei Yuanao Technology CO Ltd | +86-15377628618 +86-15377628618 |
info@yuanaotech.com | China | 6 | 58 |
Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 |
info@longyupharma.com | China | 2534 | 58 |
Cellmano Biotech Limited | 0551-65326643 18156095617 |
info@cellmano.com | China | 999 | 58 |
Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 |
sales@alabiochem.com | China | 888 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
sales@afinechem.com | China | 15386 | 58 |
Senova Technology Co. Ltd. | +86-0755-86703119 +8618503098836 |
info@senovatech.com | China | 351 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 988 | 58 |
Wuhan Cell Pharmaceutical Co., Ltd | +86-13129979210 +86-13129979210 |
sales@cellwh.com | China | 376 | 58 |
Sigma Audley | +86-15937194204 +86-18126314766 |
nova@sh-teruiop.com | China | 491 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 |
Ethan@dornechem.com | China | 3128 | 58 |
세르마글루타이드 관련 검색:
GLP-1
Dulaglutide
Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu
Semaglutide intermediate
LY1001
Sermaglutide impurity
Octreotide acetate
Oxytocin
Cetrorelix acetate
Glatiramer acetate
Glucagon
Desmopressin
Teriparatide acetate
Calcitonin salmon
Goserelin acetate
Exendin-4
Albiglutide