Phthalylsulfathiazole manufacturers and suppliers in india

Phthalylsulfathiazole

Properties

Melting point:: 198-204°C

Boiling point:: 371.31℃[at 101 325 Pa]

Density: 1.4235 (rough estimate)

vapor pressure: 0Pa at 25℃

refractive index: 1.6390 (estimate)

storage temp.: Keep in dark place,Sealed in dry,Room Temperature

solubility: Practically insoluble in water, freely soluble in dimethylformamide, slightly soluble in acetone and in ethanol (96 per cent).

pka: 3.40±0.36(Predicted)

form: Solid

color: White to Light Yellow

Water Solubility: 400mg/L at 28℃

Merck: 14,7377

BRN: 359901

LogP: -2 at 28℃

Safety Information

Symbol(GHS): GHS07,GHS08,GHS09

Signal word: Danger

Hazard statements: H412

Precautionary statements: P273-P501

Safety Statements: 24/25

RIDADR: 3249

RTECS: TH8575000

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29350090

Toxicity: LD50 i.p. in mice: 920 mg/kg (Mattis)

Use

Phthalylsulfathiazole, a sulfonamide anti-infective agent, was introduced in 1946 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. Although phthalylsulfathiazole, which is poorly absorbed from the gastrointestinal tract, is no longer recommended in some countries, it continues to be used in others for the treatment of local intestinal infections, including bacterial dysentery, and for pre-operative bowel preparation.