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Alprazolam
Alprazolam
- CAS:
- 28981-97-7
- MF:
- C17H13ClN4
- MW:
- 308.76
Properties
- Melting point:
- 228-228.50C
- Boiling point:
- 463.51°C (rough estimate)
- Density
- 1.2000 (rough estimate)
- refractive index
- 1.6110 (estimate)
- Flash point:
- 11 °C
- storage temp.
- 2-8°C
- solubility
- H2O: insoluble
- pka
- 2.37±0.40(Predicted)
- Water Solubility
- 70mg/L(ambient temperature)
- BCS Class
- 1
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312-P330-P501
- Hazard Codes
- Xn,T,F
- Risk Statements
- 22-39/23/24/25-23/24/25-11
- Safety Statements
- 36-45-36/37-16-7
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- XZ5473000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 2933910000
- Toxicity
- LD50 in mice, rats (mg/kg): 1020, >2000 orally; 540, 610 i.p. (Nakajima)
- DEA Controlled Substances
- CSCN: 2882
CAS SCH: Ⅳ
NARC: N
Use
Alprazolam, 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine (Xanax), israpidly absorbed from the GI tract. Protein binding is lower(～70%) than with most benzodiazepines because of itslower lipophilicity.α-Hydroxylation of the methyl group tothe methyl alcohol (a reaction analogous to benzylic hydroxylation)followed by conjugation is rapid; consequently,the duration of action is short. The drug is a highlypotent anxiolytic on a milligram basis.
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