Guanosine manufacturers and suppliers in india

Guanosine

Properties

Melting point:: 250 °C (dec.) (lit.)

alpha: -62 º (c=3, in 0.1 N NaOH)

Boiling point:: 425.8°C (rough estimate)

Density: 1.3790 (rough estimate)

refractive index: -76 ° (C=1, 1mol/L NaOH)

storage temp.: room temp

solubility: 0.1 M NaOH: 0.1 g/mL, clear, slightly yellow

pka: pK1:1.9(＋1);pK2:9.25(0);pK3:12.33(OH) (25°C)

form: Powder

color: White to light yellow

Odor: Odorless

optical activity: [α]20/D -73±2°, c = 1.5% in 1 M NaOH

Water Solubility: 0.75 g/L (25 ºC)

Merck: 14,4566

BRN: 625911

InChIKey: NYHBQMYGNKIUIF-UUOKFMHZSA-N

LogP: -2.331 (est)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301

Precautionary statements: P301+P310

Hazard Codes: T,Xi

Risk Statements: 25

Safety Statements: 45-24/25-23

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: MF8750000

F: 10-23

Hazard Note: Irritant

TSCA: Yes

HazardClass: 6.1

PackingGroup: Ⅲ

HS Code: 29349990

Use

Guanosine is a purine nucleoside, in which the guanine attached to the C1 carbon of a ribose (ribofuranose) ring via a -N9-glycosidic bond. Its phosphorylated derivatives include GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate), and GTP (guanosine triphosphate). These guanosine derivatives are very important in various biochemical processes, such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction. Guanosine is thought to have neuroprotective properties. It can reduce neuroinflammation, oxidative stress, and excitotoxicity, as well as exerting trophic effects in neuronal and glial cells.It is shown to be protective in central nervous system diseases including ischemic stroke, Alzheimers disease, Parkinsons disease, spinal cord injury, nociception, and depression. Guanosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency, which is an inborn error of metabolism.