Hexetidine manufacturers and suppliers in india

Hexetidine

Properties

Melting point:: 25°C

Boiling point:: 160 °C/0.4 mmHg (lit.)

Density: 0.889 g/mL at 25 °C (lit.)

refractive index: 1.4649

Flash point:: 70°C

storage temp.: 2-8°C

solubility: acetone: soluble(lit.)

form: Liquid

pka: 8.3(at 25℃)

color: Clear Colourless

Water Solubility: Not miscible or difficult to mix in water.

Merck: 14,4703

BRN: 161071

InChIKey: DTOUUUZOYKYHEP-UHFFFAOYSA-N

LogP: 7.150 (est)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P261-P264-P280-P280-P304+P340+P312-P337+P313

Hazard Codes: Xi

Risk Statements: 36/38-36/37/38

Safety Statements: 26-36

WGK Germany: 3

Hazard Note: Irritant

TSCA: Yes

HS Code: 2933599590

Use

Hexetidine is mainly used in mouthwashes as a bactericidal and fungicidal antiseptic. It is also used as an antimicrobial preservative and is generally regarded as a relatively nontoxic and nonirritant material at concentrations up to 0.1% w/v. Allergic contact dermatitis and altered olfactory and taste perception have occasionally been reported. Hexetidine is toxic when administered intravenously. Solutions of hexetidine in oil at concentrations of 5–10% w/v cause strong primary irritations without sensitization in humans. Long-term toxicological studies of up to 0.1% w/w of hexetidine in food for 1 year do not show any toxic effect. Fetotoxicity, embryotoxicity, and teratogenicity studies in rats of doses up to 50 mg/kg/day exhibit no sign of toxicity. LD100 (cat, IV): 5–20 mg/kg LD50 (dog, oral): 1.60 g/kg LD50 (mouse, IP): 0.142 g/kg LD50 (mouse, oral): 1.52 g/kg LD50 (rat, oral): 0.61–1.43 g/kg