IMD-0354
IMD-0354
- CAS:
- 978-62-1
- MF:
- C15H8ClF6NO2
- MW:
- 383.67
Suppliers by country/region
Company Type
Properties
- Boiling point:
- 323.1±42.0 °C(Predicted)
- Density
- 1.561
- storage temp.
- -20°C
- solubility
- DMSO (5 mg/ml) or Ethanol (1 mg/ml).
- form
- White solid
- pka
- 7.61±0.43(Predicted)
- color
- White to off-white
- Sensitive
- Light Sensitive
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P280a-P304+P340-P305+P351+P338-P405-P501a
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- HS Code
- 29242990
Use
IMD 0354 is an IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation. It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1β and MCP-1 production, resulting in suppressed neutrophil accumulation in a rat model of ischemia/reperfusion injury. IMD 0354, suppresses the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis. It induces apoptosis of chronic lymphocytic leukemia cells at 1-10 μM by directly targeting the NF-κB pathway, decreasing expression of anti-apoptotic genes and increasing expression of proapoptotic genes.
1 India supplier list of "IMD-0354"
- Product Name:IKK-2InhibitorV-CAS978-62-1-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:401482 | Purity:TheIKK-2InhibitorV,alsoreferencedunderCAS978-62-1,controlsthebiologicalactivityo
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Imd 0354 95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.193288
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:IMD0354
- Products Intro:Brand:clearsynth | Product Number:CS-T-29153
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:IMD-0354
- Products Intro:Brand:ajchemicals | Product Number:JDH-31336 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:IMD-0354
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:IMD 0354
- Products Intro:Purity: >98% | Package: 50mg | CustNote: BOC Sciences also provides custom synthesis services for IMD 0354.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
- Products Intro:Purity: 98% | Package: 25ASSAYS;USD
- Company Type: Trader
- Country/Region: CHINA
- Product Name:IMD-0354
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:IMD 0354
- Products Intro:Package: 1g; 5g; 25g; 1kg; 5kg; 25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: pharmaceuticals,intermediates,fine chemicals,screening compounds,building blocks