L-Thyroxine
L-Thyroxine
- CAS:
- 51-48-9
- MF:
- C15H11I4NO4
- MW:
- 776.87
Suppliers by country/region
Company Type
Properties
- Melting point:
- 235 °C
- alpha
- -5 º (1N NaOH:EtOH 1:2)
- Density
- 2.4440 (estimate)
- Flash point:
- 9℃
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Dissolves in 4M ammonium hydroxide in Methanol at 50mg/ml
- pka
- 2.2(at 25℃)
- Boiling point:
- 576.3±50.0 °C(Predicted)
- form
- Powder
- color
- White to Pale Brown
- optical activity
- -4.5 to -5.7 [1 mol dm-3 NaOH-ethanol (1:2)] +15 [1 mol dm-3 HCl-95% ethanol (1:2)]
- Water Solubility
- insoluble
- Sensitive
- Light Sensitive
- Merck
- 9491
- BRN
- 2228515
- InChIKey
- XUIIKFGFIJCVMT-LBPRGKRZSA-N
Safety Information
- Symbol(GHS)
GHS02,GHS06,GHS08
- Signal word
- Danger
- Hazard statements
- H225-H301+H311+H331-H370
- Precautionary statements
- P210-P260-P280-P301+P310+P330-P302+P352+P312-P370+P378
- Hazard Codes
- Xn,T,F
- Risk Statements
- 40-39/23/24/25-23/24/25-11
- Safety Statements
- 22-24/25-36-45-36/37-16
- RIDADR
- UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany
- 3
- RTECS
- YP2833500
- F
- 8-10
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29379000
- Toxicity
- TDLo oral in child: 328ug/kg
Use
L-thyroxine is the major hormone derived from the thyroid gland. It is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines(diiodotyrosine)in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine that exerts a broad spectrum of stimulatory effects on cell metabolism. It is mainly used for the treatment of hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, and stupor[1]. The thyroid gland is responsible for the synthesis, storage and release of metabolic hormones including iodine-containing thyroxine(T4) and triiodothyroxine(T3). These hormones are crucial in the regulation of many metabolic processes and are vital for normal growth and development. They are also involved in calorigenic, cardiovascular and metabolic effects. The hormones exert their effects presumably by activating gene transcription of messenger RNA and proteins. To do so, they enter the cell nucleus and bind to DNA-bound thyroid receptors, which regulate gene transcription[2, 3].
9 India supplier list of "L-Thyroxine"
- Product Name:LEVOTHYROXINE
- Products Intro:Purity: 98.62 | Package: Customize Packaging (As per customer requirement in Miligram)
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Levothyroxine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Levothyroxine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Levothyroxine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Levothyroxine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Levothyroxine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:L-THYROXINE SODIUM
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Levothyroxine
- Products Intro:Brand:sigma aldrich | Product Number:PHR1613 | Purity:PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial
- Company Type: Trader
- Country/Region: INDIA
- Product Name:LiothyronineEPImpurityA
- Products Intro:Brand:synzeal | Product Number:128624701
- Company Type: Trader
- Country/Region: INDIA