Olopatadine hydrochloride
Olopatadine hydrochloride
- CAS:
- 140462-76-6
- MF:
- C21H24ClNO3
- MW:
- 373.88
Suppliers by country/region
Company Type
Properties
- Melting point:
- 242-245?C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- H2O: ≥20mg/mL
- form
- solid
- color
- White to Light yellow
- Merck
- 14,6840
- BCS Class
- 3(CLogP), 1 (LogP)
- InChI
- InChI=1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;
- InChIKey
- HVRLZEKDTUEKQH-NOILCQHBSA-N
- SMILES
- C(=C1/C2=CC=CC=C2COC2C=CC(CC(=O)O)=CC/1=2)\CCN(C)C.Cl
Safety Information
- Symbol(GHS)
GHS06,GHS09
- Signal word
- Danger
- Hazard statements
- H301-H400
- Precautionary statements
- P273-P301+P310+P330
- Hazard Codes
- T,N
- Risk Statements
- 25-50
- Safety Statements
- 45-61
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- RTECS
- HQ4135060
- HS Code
- 29329990
Use
Olopatadine hydrochloride is a potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively). It blocks histamine-induced phosphoinositide turnover in isolated cells (IC50 = 9.5-39.9 nM) and prevents passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and anaphylactic bronchoconstriction in guinea pigs (ID50 = 30 μg/kg). Olopatadine is effective in treating allergic rhinitis and conjunctivitis. It also suppresses itch in patients with well-controlled chronic urticaria. In humans, this antihistamine does not cause cognitive or psychomotor impairment at therapeutic doses.[Cayman Chemical]
61 India supplier list of "Olopatadine hydrochloride"
- Product Name:OLOPATADINE HYDROCHLORIDE
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:OLOPATADINE HCL
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Olopatadine hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Olopatadine hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Olopatadine hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Olopatadine hydrochloride
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Olopatadine hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Olopatadine hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Olopatadine hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Olopatadine hydrochloride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA