Panipenem manufacturers and suppliers in india

Panipenem

Properties

Melting point:: 198-200° (dec)

Boiling point:: 555.5±60.0 °C(Predicted)

Density: 1.62±0.1 g/cm3(Predicted)

storage temp.: Amber Vial, Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility: DMSO (Slightly), Methanol (Very Slightly), Water (Slightly)

pka: 4.30±0.40(Predicted)

form: Solid

color: White to Off-White

Stability:: Hygroscopic, Light Sensitive

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

Toxicity: Approx LD50 in male, female mice (mg/kg): 1700-2200, 1300-1700 i.v. (Kimura)

Use

Panipenem is a carbapenem antibiotic,it is successfully developed by Japan Sankyo ,it has a broad antimicrobial spectrum , and it has strong antibacterial activity. To further enhance security, the antibiotic and kidney-protecting agent organic ion transport inhibitors Betamipron as 1:1 ratio are usd for the synthesis of compound preparation, Betamipron does not inhibit the dehydrogenation peptidase,it also has no inhibitory and other pharmacological effects, it only suppresses organic ion transport,it reduces kidney toxicity, it is clinically used for the treatment of bacteremia, sepsis, cholecystitis, liver abscess, peritonitis, inflammation of the eye, otitis media, endocarditis, skin and soft tissue infections, lower respiratory tract infections, genitourinary infections, gynecological infections caused by staphylococcus, streptococcus, enterococcus and other sensitive strains.