Pranlukast manufacturers and suppliers in india

Pranlukast

Properties

Melting point:: 236-238°C

Density: 1.374±0.06 g/cm3(Predicted)

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: Soluble in DMSO (up to 25 mg/ml)

form: solid

pka: 4.96±0.10(Predicted)

color: White

Merck: 14,7710

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H413

Precautionary statements: P501-P273-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Hazard Codes: F,C

Risk Statements: 11-34

Safety Statements: 16-26-36/37/39-45

RTECS: CV5647500

HS Code: 2934.99.4400

Toxicity: LD50 in male mice (mg/kg): >1000 i.v. (Toda)

Use

Pranlukast, a novel chromone derivative, was introduced in Japan for the treatment of bronchial asthma and allergic diseases. Pranlukast is a highly potent, selective and competitive antagonist of peptidoleukotrienes with high affinity for the LTD4 receptor. In patients with bronchial asthma, pranlukast was reported to induce significant improvement in both immediate and late asthmatic response induced by antigen. Pranlukast is also being evaluated clinically for the treatment of perennial allergic rhinitis, pediatric asthma, and cutaneous pruritus in dialysis patients. The therapeutic potential of pranlukast in managing irritable bowel syndrome has been suggested.