TOLBUTAMIDE manufacturers and suppliers in india

TOLBUTAMIDE

Properties

Melting point:: 128-130°C

Density: 1.2450

refractive index: 1.6360 (estimate)

storage temp.: Sealed in dry,Room Temperature

solubility: Soluble in chloroform.

form: Solid

pka: pKa 5.32(H2O t = 37) (Uncertain)

color: White to Off-White

biological source: synthetic (organic)

Water Solubility: 0.14g/L(25 ºC)

Merck: 14,9507

BRN: 1984428

Specific Activity: 50-60 mCi/mmol

Concentration: 0.1 mCi/ml

Solvent: Ethanol

Stability:: Stable. Combustible.

CAS DataBase Reference: 64-77-7(CAS DataBase Reference)

EPA Substance Registry System: Tolbutamide (64-77-7)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H317

Precautionary statements: P261-P280g-P301+P312a-P321-P333+P313-P501a

Hazard Codes: F,Xn

Risk Statements: 20/21/22-40-43-36-11

Safety Statements: 26-36/37/39-36/37-16-24/25

WGK Germany: 2

RTECS: YS4550000

TSCA: Yes

HS Code: 29350090

Hazardous Substances Data: 64-77-7(Hazardous Substances Data)

Toxicity: LD50 oral in rat: 2490mg/kg

Use

Tolbutamide, 1-butyl-3-(p-tolylsulfonyl)urea (Orinase), occurs as a white, crystalline powderthat is insoluble in water and soluble in alcohol or aqueousalkali. It is stable in air.Tolbutamide is absorbed rapidly in responsive diabetic patients.The blood sugar level reaches a minimum after 5 to8 hours. It is oxidized rapidly in vivo to 1-butyl-3-(p-carboxyphenyl)sulfonylurea, which is inactive. The metabolite isfreely soluble at urinary pH; if the urine is strongly acidified,however, as in the use of sulfosalicylic acid as a protein precipitant,a white precipitate of the free acid may be formed.