TOLAZAMIDE manufacturers and suppliers in india

TOLAZAMIDE

Properties

Melting point:: 162-164°C

Boiling point:: 300°C (rough estimate)

Density: 1.2228 (rough estimate)

refractive index: 1.6740 (estimate)

storage temp.: Sealed in dry,Room Temperature

solubility: Very slightly soluble in water; freely soluble in chloroform; soluble in acetone; slightly soluble in ethanol (96%).

form: Solid

pka: 3.6(at 25℃)

color: White to Off-White

Water Solubility: 65.4mg/L(30 ºC)

CAS DataBase Reference: 1156-19-0(CAS DataBase Reference)

EPA Substance Registry System: Tolazamide (1156-19-0)

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H370

Precautionary statements: P260-P264-P270-P307+P311-P321-P405-P501

Hazard Codes: Xn

Risk Statements: 22

Safety Statements: 36

WGK Germany: 3

RTECS: YT4400000

HS Code: 2935904000

Hazardous Substances Data: 1156-19-0(Hazardous Substances Data)

Toxicity: LD50 in rats, mice (mg/kg): >5000 orally, 2239 i.p. (Dulin)

Use

Tolazamide, 1-(hexahydro-1Hazepin-1-yl)-3-(p-tolylsulfonyl)urea (Tolinase), is an analogof tolbutamide and is reported to be effective, in general,under the same circumstances in which tolbutamide is useful.Tolazamide, however, appears to be more potent than tolbutamideand is nearly equal in potency to chlorpropamide. Instudies with radioactive tolazamide, investigators found that85% of an oral dose appeared in the urine as metabolites thatwere more soluble than tolazamide itself.