5-Fluoroorotic acid
5-Fluoroorotic acid
- CAS:
- 703-95-7
- MF:
- C5H3FN2O4
- MW:
- 174.09
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Company Type
Properties
- Melting point:
- 278 °C (dec.)(lit.)
- Boiling point:
- 143°C (rough estimate)
- Density
- 1.6154 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- NH4OH 4 M: 50 mg/mL, clear, faintly yellow
- pka
- 2.04±0.20(Predicted)
- form
- solid
- color
- Pale yellow
- Merck
- 14,4176
- InChIKey
- LODRRYMGPWQCTR-UHFFFAOYSA-N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P264-P270-P301+P312+P330-P501-P261-P305+P351+P338
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36-36/37/39-27
- WGK Germany
- 3
- RTECS
- UV7800000
- F
- 10
- HazardClass
- IRRITANT
- HS Code
- 29335990
Use
5-FOA(5-Fluoroorotic acid ) has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.
5 India supplier list of "5-Fluoroorotic acid "
- Product Name:5-Fluoroorotic acid
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:5-FluorooroticAcid(5-FOA)formolecularbiology,98%
- Products Intro:Brand:trivenichemical | Product Number:78510
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:5-Fluoroorotic acid
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:5-Fluoroorotic acid
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:5-Fluoroorotic acid
- Company Type: Reagent
- Country/Region: Hyderabad,INDIA
- Product Name:5-FluorooroticAcid(5-FOA)formolecularbiology,98%
- Products Intro:Brand:srlchem | Product Number:78510
- Company Type: Trader
- Country/Region: Mumbai,INDIA
- Product Name:5-Fluoroorotic acid
- Company Type: Trader
- Country/Region: Delhi,INDIA
- Product Name:5-Fluorooroticacid
- Products Intro:Brand:ajchemicals | Product Number:JDH-48292 | Purity:96%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:5-Fluoroorotic Acid
- Products Intro:Purity: 98%|Package: 1KG;10.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: acetic acid,Ethyl oleate,Hypophosphorous acid,tetramisole,OPP
$10.00/ 1KG
- Product Name:5-Fluoroorotic acid,5-FOA
- Products Intro:Purity: 99% | Package: 1KG,5KG 10KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: OLED/LCD chemicals,Reactive Mesogens,Silane,Silicon