Trifluridine manufacturers and suppliers in india

Trifluridine

Properties

Melting point:: 190-193 °C (lit.)

Density: 1.4365 (estimate)

refractive index: 50 ° (C=1, H2O)

storage temp.: 2-8°C

solubility: Soluble in DMSO (up to 25 mg/ml) or in Water (up to 14 mg/ml)

form: solid

pka: pKa 7.85 (Uncertain)

color: Off-white

Merck: 14,9687

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H341-H351-H361d

Precautionary statements: P201-P202-P280-P308+P313-P405-P501

Hazard Codes: Xn,Xi

Risk Statements: 20/21/22-40

Safety Statements: 22-36

WGK Germany: 3

RTECS: XP2087500

Hazard Note: Keep Cold

HS Code: 29349990

Toxicity: LD50 intraperitoneal in mouse: 1931mg/kg

Use

Trifluridine (trifluorothymidine, TFT), a fluorinated pyrimidine nucleoside, is an anti-herpesvirus agent and an antitumor antimetabolite agent. It is an analog of thymidine which inhibits thymidylate synthase possesses antiviral and anticancer activity. After phosphorylation by thymidine kinase, it is incorporated into DNA where it induces DNA-damage and interferes with repair enzymes. Enhances frame shift insertion and deletion in CRISPR genome editing in pluripotent stem cells.