AVL-292
AVL-292
- CAS:
- 1202757-89-8
- MF:
- C22H22FN5O3
- MW:
- 423.44
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Company Type
Properties
- Density
- 1.322±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥21.15 mg/mL in DMSO; insoluble in H2O; ≥4.9 mg/mL in EtOH with gentle warming and ultrasonic
- form
- solid
- pka
- 13.22±0.70(Predicted)
- color
- White to khaki
- CAS DataBase Reference
- 1202757-89-8
Safety Information
Use
Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells. AVL-292 is an orally available, selective, and irreversible inhibitor of BTK (IC50 = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481, thereby preventing its activity. AVL-292 has been shown to inhibit osteoclast function and to reduce osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid arthritis and multiple sclerosis, both of which are diseases where B cells play an important role. In clinical trials, AVL-292 has demonstrated therapeutic significance in the treatment of both B cell-related cancers (e.g., non-Hodgkin’s lymphoma and B cell chronic lymphocytic leukemia) and autoimmune diseases (e.g., rheumatoid arthritis).[Cayman Chemical]
1 India supplier list of "AVL-292"
- Product Name:AVL-292 >95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.089854
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Spebrutinib
- Products Intro:Brand:pharmaffiliates | Product Number:PA191730000
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:AVL-292
- Products Intro:Brand:ajchemicals | Product Number:JDH-26422 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:N-(3-((5-fluoroethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide （AVL-292)
- Products Intro:Purity: 0.99 | Package: 5KG;1KG | CustNote: Have any requirements, pls contact sales@zetchem.com
- Company Type: Trader
- Country/Region: CHINA
- Main Products: pharmaceutical, agrochemical, speciality chemical and liquid crystal industries.
- Product Name:AVL-292
- Products Intro:Purity: 98% | Package: 1 g | CustNote: Reach out to us for more information about custom solutions.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:Spebrutinib；AVL-292;LMK-435;CC-292
- Products Intro:Purity: 100.00% | Package: 1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；25 mg；5 mg；50 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:AVL-292
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:AVL-292
- Products Intro:Purity: 98% | Package: 5g, 25g, 100g, 500g, 1kg, 25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Chemical reagent,Pharmaceutical intermediates,Catalyst