lubiprostone
lubiprostone
- CAS:
- 333963-40-9
- MF:
- C20H32F2O5
- MW:
- 390.46
Suppliers by country/region
Company Type
Properties
- Boiling point:
- 532.3±50.0 °C(Predicted)
- Density
- 1.175
- storage temp.
- -20°C Freezer
- pka
- 4.77±0.10(Predicted)
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
Use
Chronic constipation is an affliction affecting 4–5 million Americans alone. When no specific cause is identified, it is classified as idiopathic. Dietary and lifestyle modifications are the first-line conventional approaches followed by the administration of laxatives. Unfortunately, chronic idiopathic constipation is frequently refractory to traditional therapy; thus, the need for novel agents exists. Lubiprostone is a bicyclic fatty acid with a novel mechanism of action. Without affecting sodium and potassium ion concentrations, lubiprostone activates intestinal chloride ion channels, thereby, increasing intestinal water secretion and intestinal fluid chloride ion concentration. In basolateral membranepermeabilized T84 gastrointestinal epithelial cells under chloride gradient conditions, lubiprostone concentration-dependently increased short-circuit current with an EC50 of approximately 20 nM.
8 India supplier list of "lubiprostone"
- Product Name:lubiprostone
- Company Type: Service provider
- Country/Region: New Delhi,INDIA
- Product Name:Lubiprostone
- Company Type: Reagent
- Country/Region: Hyderabad,INDIA
- Product Name:Lubiprostone
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:LUBIPROSTONE
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Amitiza Lubiprostone
- Company Type: Reagent
- Country/Region: Bangalore,INDIA
- Product Name:7-((1R,2S)-2-(4,4-Difluoro-3-oxooctyl)-5-oxocyclopent-3-en-1-yl)heptanoicAcid
- Products Intro:Brand:pharmaffiliates | Product Number:PA120871001
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:LUBIPROSTONE
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:LUBIPROSTONE
- Company Type: Manufacturer
- Country/Region: New Delhi,INDIA
- Product Name:Lubiprostone
- Company Type: Reagent
- Country/Region: Mumbai,INDIA
- Product Name:Lubiprostone
- Products Intro:Purity: 99% up|Package: 10G/Bag;0.00;USD|100G/Bag;0.00;USD|1000G/Bag;0.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: APIs,pharmaceutical intermediates,health and food supplements,cosmetic raw materials,herbal extracts
$0.00-0.00 / 10G/Bag