Trametinib
Trametinib
- CAS:
- 871700-17-3
- MF:
- C26H23FIN5O4
- MW:
- 615.39
Suppliers by country/region
Company Type
Properties
- Melting point:
- 300-301 °C
- Density
- 1.74
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 20 mg/ml)
- form
- White solid.
- pka
- 14.76±0.70(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- InChIKey
- LIRYPHYGHXZJBZ-UHFFFAOYSA-N
- SMILES
- C(NC1=CC=CC(N2C3=C(C)C(=O)N(C)C(NC4=CC=C(I)C=C4F)=C3C(=O)N(C3CC3)C2=O)=C1)(=O)C
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Danger
- Hazard statements
- H317-H361-H372
- Precautionary statements
- P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P201-P202-P281-P308+P313-P405-P501-P260-P264-P270-P314-P501
- Safety Statements
- 24/25
- HS Code
- 29339900
Use
Trametinib is an oral MEK inhibitor which has demonstrated excellent results in combination therapy for BRAF-mutated melanoma and is FDA approved in combination with BRAF inhibitors for that indication. Trametinib was evaluated initially as a single agent in KRAS mutant NSCLC in comparison with docetaxel and pemetrexed. Results as a single agent were not impressive, with an ORR of only 12% in these patients.
2 India supplier list of "Trametinib"
- Product Name:Trametinib 99% (HPLC)
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.095186
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Trametinib
- Products Intro:Brand:pharmaffiliates | Product Number:PA4714000
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Trametinib
- Products Intro:Brand:ajchemicals | Product Number:JDH-38052 | Purity:98+%
- Company Type: Trader
- Country/Region: INDIA
- Product Name:TrametinibD4
- Products Intro:Brand:clearsynth | Product Number:CS-O-13374
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Trametinib
- Products Intro:Purity: 0.99 | Package: 500g；1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Trametinib
- Products Intro:Purity: 98%|Package: 1KG;10.00;USD
- Company Type: Trader
- Country/Region: CHINA
$10.00/ 1KG
- Product Name:Trametinib
- Products Intro:Purity: 98%+ | Package: 1kg;5kg;10kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyr
- Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Trametinib
- Products Intro:Purity: As coa | Package: As request | CustNote: 871700-17-3
- Company Type: Trader
- Country/Region: CHINA