11-DEOXY PROSTAGLANDIN E1
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- Product name: 11-DEOXY PROSTAGLANDIN E1
- CAS: 37786-00-8
- MF: C20H34O4
- MW: 338.48
- EINECS:
- MDL Number:MFCD00065738
- Synonyms:11-DEOXY PROSTAGLANDIN E1;9-OXO-15S-HYDROXY-PROST-13E-EN-1-OIC ACID;7-((1R,2R)-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)heptanoic acid;11-deoxy Prostaglandin E1 Exclusive;Prost-13-en-1-oic acid, 15-hydroxy-9-oxo-, (13E,15S)-
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Properties
Boiling point :509.7±35.0 °C(Predicted)
Density :1.070±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: >100 mg/ml (from PGE1); DMSO: >50 mg/ml (from PGE1); Ethanol: >50 mg/ml (from PGE1); PBS pH 7.2: >1.6 mg/ml (from PGE1)
form :A crystalline solid
pka :4.77±0.10(Predicted)
Density :1.070±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: >100 mg/ml (from PGE1); DMSO: >50 mg/ml (from PGE1); Ethanol: >50 mg/ml (from PGE1); PBS pH 7.2: >1.6 mg/ml (from PGE1)
form :A crystalline solid
pka :4.77±0.10(Predicted)
Safety Information
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| Signal word: | Danger | ||||||||||||||||||||||
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Description
11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1. Early reports show that it is a selective agonist for the EP2 receptor but effective at much higher concentrations than PGE2. However, later studies show that it is a non-selective agonist of EP receptors and stimulates cAMP release in Jurkat cells with an EC50 of 0.25 μM. 11-deoxy PGE1 also exhibits vasodepressor and bronchodilator responses in guinea pigs. 11-deoxy PGE1 exhibits selectively for the mouse EP3 receptor and is essentially equipotent to PGE1 at this receptor subtype. The Ki values for binding to the mouse EP1, EP2, EP3, and EP4 receptors are 600, 45, 1.1, and 23 nM, respectively.Related product price
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Suppliers and manufacturers
Aladdin Scientific
Nantong Hanfang Biotechnology Co. , Ltd.
TargetMol Chemicals Inc.
3B Scientific Corporation
CHEMICAL LAND21
CARBONE SCIENTIFIC CO.,LTD
Shanghai Synchem Pharma Co., ltd
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Shenzhen Xinbosheng Biological Technology Co., Ltd.
Shanghai Benrui Biotechnology Co., Ltd.