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(R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride

(R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride Structure
  • ₹0
  • Product name: (R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride
  • CAS: 1204818-19-8
  • MF: C10H11ClF3NO2
  • MW: 269.6480496
  • EINECS:
  • MDL Number:MFCD06659146
  • Synonyms:(R)-b-Amino-2,4,5-trifluoro-benzenebutanoic acid HCl;Sitagliptin Impurity 17;Sitagliptin Acid Impurity HCl;Sitagliptin-2;Sitagliptin impurity 37/(R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid hydrochloride;(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid,hydrochloride;(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid hydrochloride;(3R)-3-amino -4-(2, 4-difluorophenyl)-1-[3-(trifluoromethyl)butyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :218-220℃
storage temp. :Inert atmosphere,Room Temperature
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White to Off-White
Sensitive :Air Sensitive
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride is an intermediate in the synthesis of the new antidiabetic drug Sitagliptine (S491000); a trizolopyrazine dipeptidyl peptidase IV inhibitor.

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Sitagliptin 243139-71-1 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER 5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione 762240-92-6 762240-99-3 BOC-(R)-3-AMINO-4-(3,4-DIFLUORO-PHENYL)-BUTYRIC ACID Sitagliptin Defuoro IMpurity 3 2,3,5-TRIFLUOROPHENYLACETIC ACID 2,4,5-Trifluorophenylacetic acid 658-93-5 Ethyl trifluoroacetate 81228-09-3 85068-27-5 Sitagliptin phosphate N'-[(2Z)-Piperazin-2-ylidene]trifluoroacetohydrazide VINYLIDENE CHLORIDE 2,2-Dimethyl-1,3-dioxane-4,6-dione

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