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Sitagliptin phosphate

Sitagliptin phosphate Structure
  • ₹0
  • Product name: Sitagliptin phosphate
  • CAS: 654671-78-0
  • MF: C16H15F6N5O.H3PO4
  • MW: 505.31
  • EINECS:1806241-263-5
  • MDL Number:MFCD09952339
  • Synonyms:7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine-phosphate;Sitagliptin phosphate;4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate;sitagpliptin;Sitagliptin phosphate 4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate;Sitagliptin phosphate/Sitagliptin phosphate Monohydrate/Sitagliptin;Sitagliptin phosphate (Cas:654671-78-0...;(3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone phosphate
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :202-204°C
storage temp. :-20°C Freezer
solubility :Methanol (Slightly, Heated), Water (Sparingly, Sonicated)
form :Solid
color :White to Off-White
InChI :InChI=1S/C16H15F6N5O.H3O4P/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4)
InChIKey :IQFYVLUXQXSJJN-UHFFFAOYSA-N
SMILES :C(C1=CC(F)=C(F)C=C1F)C(N)CC(=O)N1CCN2C(C(F)(F)F)=NN=C2C1.P(O)(O)(O)=O

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Dipeptidyl peptidase 4 (DPP-4) is an intrinsic membrane glycoprotein that acts as an exopeptidase, cleaving oligopeptides after the second amino acid from the N-terminal end. One of its substrates is glucagon-like peptide 1, an incretin that stimulates insulin biosynthesis and secretion while inhibiting glucagon release in a glucose-dependent manner. Sitagliptin is a potent inhibitor of DPP-4 (IC50 = 18 nM). It only modestly inhibits DPP-8 (IC50 = 48 μM) and is without effect on several related peptidases, including DPP-9, DPP-II, and amino peptidase P. Sitagliptin is orally active, rapidly absorbed, and inhibits DPP-4 in plasma. It lowers fasting plasma glucose, glycosylated hemoglobin, and two-hour postprandial glucose levels in patients with type 2 diabetes. In addition to having use in type 2 diabetes, gliptins, including sitagliptin, have positive cardiovascular and anti-inflammatory effects.

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Suppliers and manufacturers

SURYA LIFE SCIENCES LIMITED ANWITA APIS Dr. Reddy's Laboratories Ltd Bulat Pharmaceutical Pvt Ltd SKVen Technologies Pvt.Ltd. AARTIA KEM SCIENCE Sekhment pharmaventures Aurobindo Pharma Limited Aalidhra Pharmachem Pvt Ltd Honour Lab Limited