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R(+)-ARACHIDONYL-1'-HYDROXY-2'-PROPYLAMIDE

R(+)-ARACHIDONYL-1'-HYDROXY-2'-PROPYLAMIDE Structure
  • ₹0
  • Product name: R(+)-ARACHIDONYL-1'-HYDROXY-2'-PROPYLAMIDE
  • CAS: 157182-49-5
  • MF: C23H39NO2
  • MW: 361.56
  • EINECS:200-578-6
  • MDL Number:MFCD00467914
  • Synonyms:AM 356;(R)-METHANANDAMIDE;R(+)-METHANANDAMIDE;(R)-N-(2-HYDROXY-1-METHYLETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;N-(2-HYDROXY-1R-METHYLETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;N-(2R-HYDROXYPROPYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;R-1 METHANANDAMIDE;R-2 METHANANDAMIDE
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :529.0±50.0 °C(Predicted)
Density :0.935±0.06 g/cm3(Predicted)
RTECS :JX3848000
Flash point :14℃
storage temp. :−20°C
solubility :DMF: >10 mg/ml; DMSO: >30 mg/ml; Ethanol: >100 mg/ml; Ethanol:PBS (1:2): 8.5 mg/ml; PBS (pH 7.2): <100 μg/ml
pka :14.51±0.10(Predicted)
form :Colorless oil.
optical activity :[α]/D +8.7°, c = 4 in chloroform(lit.)
Sensitive :Air & Light Sensitive

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.

Description

R-1 methanandamide is the most potent CB1 receptor agonist in the methanandamide series. It has a Ki value of 20 nM for the CB1 receptor, which is four-fold lower than that of arachidonoyl ethanolamide (AEA) (Ki =78 nM). In addition, R-1 methanandamide is more resistant than AEA to hydrolytic inactivation by fatty acid amide hydrolase. The Ki value for binding to the CB2 receptor from mouse spleen is 815 nM.

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