R(+)-ARACHIDONYL-1'-HYDROXY-2'-PROPYLAMIDE
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- ₹0
- Product name: R(+)-ARACHIDONYL-1'-HYDROXY-2'-PROPYLAMIDE
- CAS: 157182-49-5
- MF: C23H39NO2
- MW: 361.56
- EINECS:200-578-6
- MDL Number:MFCD00467914
- Synonyms:AM 356;(R)-METHANANDAMIDE;R(+)-METHANANDAMIDE;(R)-N-(2-HYDROXY-1-METHYLETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;N-(2-HYDROXY-1R-METHYLETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;N-(2R-HYDROXYPROPYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;R-1 METHANANDAMIDE;R-2 METHANANDAMIDE
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Properties
Boiling point :529.0±50.0 °C(Predicted)
Density :0.935±0.06 g/cm3(Predicted)
RTECS :JX3848000
Flash point :14℃
storage temp. :−20°C
solubility :DMF: >10 mg/ml; DMSO: >30 mg/ml; Ethanol: >100 mg/ml; Ethanol:PBS (1:2): 8.5 mg/ml; PBS (pH 7.2): <100 μg/ml
pka :14.51±0.10(Predicted)
form :Colorless oil.
optical activity :[α]/D +8.7°, c = 4 in chloroform(lit.)
Sensitive :Air & Light Sensitive
Density :0.935±0.06 g/cm3(Predicted)
RTECS :JX3848000
Flash point :14℃
storage temp. :−20°C
solubility :DMF: >10 mg/ml; DMSO: >30 mg/ml; Ethanol: >100 mg/ml; Ethanol:PBS (1:2): 8.5 mg/ml; PBS (pH 7.2): <100 μg/ml
pka :14.51±0.10(Predicted)
form :Colorless oil.
optical activity :[α]/D +8.7°, c = 4 in chloroform(lit.)
Sensitive :Air & Light Sensitive
Safety Information
Symbol(GHS): |
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Signal word: | Danger | |||||||||||||||||||||||||||||||||||
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Description
R-1 methanandamide is the most potent CB1 receptor agonist in the methanandamide series. It has a Ki value of 20 nM for the CB1 receptor, which is four-fold lower than that of arachidonoyl ethanolamide (AEA) (Ki =78 nM). In addition, R-1 methanandamide is more resistant than AEA to hydrolytic inactivation by fatty acid amide hydrolase. The Ki value for binding to the CB2 receptor from mouse spleen is 815 nM.More related product prices
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