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ACPA

ACPA Structure
  • ₹0
  • Product name: ACPA
  • CAS: 229021-64-1
  • MF: C23H37NO
  • MW: 343.55
  • EINECS:
  • MDL Number:MFCD02683582
  • Synonyms:ACPA;ARACHIDONYLCYCLOPROPYLAMIDE;ARACHIDONOYL CYCLOPROPYLAMIDE;N-(CYCLOPROPYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;α-Amino-3-carboxy-5-methyl-4-isoxazolepropionic acid;α-Amino-3-carboxy-5-methylisoxazole-4-propionic acid;ACPA (in Tocrisolve(TM) 100);(5Z,8Z,11Z,14Z)-N-Cyclopropyl-5,8,11,14-eicosatetraenaMide
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :502.4±50.0 °C(Predicted)
Density :0.93±0.1 g/cm3(Predicted)
RTECS :JX3841600
storage temp. :−20°C
solubility :DMSO: soluble
pka :16.13±0.20(Predicted)
form :Pale yellow oil.
color :Colorless to light yellow
Sensitive :Air Sensitive

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

Description

Arachidonoyl ethanolamide (AEA) was the first endogenous cannabinoid to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as tetrahydrocannabinols (THC). Arachidonoyl cyclopropamide (ACPA) is a potent, stable, and selective agonist analog of AEA. ACPA has an Ki value of 2.2 nM at the isolated rat CB1 receptor, and is 325 times more potent at the CB1 receptor compared with the CB2 receptor. In whole animal experiments, ACPA induces hypothermia in mice with the same efficacy as AEA, in spite of its much higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACPA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.

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