N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide
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- ₹0
- Product name: N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide
- CAS: 1693731-40-6
- MF: C32H32N4O5
- MW: 552.62
- EINECS:-0
- MDL Number:MFCD30738050
- Synonyms:CCT251236;N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide;N-[5-(2,3-dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide;CS-2478;CCT251236;CCT-251236;CCT 251236;6-Quinolinecarboxamide, N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-methylphenyl]-2-[2-(1-pyrrolidinyl)ethoxy]-;CCT-251236,CCT251236
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Properties
Boiling point :628.7±55.0 °C(Predicted)
Density :1.328±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (5 mg/ml)
form :solid
pka :12.18±0.70(Predicted)
color :Off-white/beige
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Density :1.328±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (5 mg/ml)
form :solid
pka :12.18±0.70(Predicted)
color :Off-white/beige
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
CCT251236 (1693731-40-6) is an inhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HSP72 induction, IC50 = 40 nM HSPA1A induction).1 It displayed efficacy in a human ovarian carcinoma xenograft mouse model (SK-OV 3 cells) and inhibited migration of WM266.4 melanoma cells @ 100 nM. CCT251236 showed high affinity for the protein pirin (Ki = 28 nM), but this target was not shown conclusively to be the cause of the anticancer activity. It also showed efficacy in vitro against primary patient-derived myeloma cells and H929 human myeloma xenograft models.2Related product price
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
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Aladdin Scientific
Amadis Chemical Company Limited
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Shanghai Hao Zhun Biological Technology Co., Ltd.
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.
Shanghai Changyan Chem & Tech Co., Ltd.