Carbonic Anhydrase IX/XII Inhibitor II(U-104)
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- ₹10846.65 - ₹43830.43
- Product name: Carbonic Anhydrase IX/XII Inhibitor II(U-104)
- CAS: 178606-66-1
- MF: C13H12FN3O3S
- MW: 309.32
- EINECS:
- MDL Number:MFCD00159265
- Synonyms:NSC 213841;Carbonic Anhydrase IX/XII Inhibitor II(U-104);U-104;MST-104 ;4-[[[(4-Fluorophenyl)amino]carbonyl]amino]benzenesulfonamide;U104/NSC 213841/MST104;U-104;NSC 213841;U 104;4-[[[(4-Fluorophenyl)aMino]carbonyl]aMino]-benzenesulfonaMide, NSC 213841
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0374
- Product descriptionU-104 ≥98% (HPLC)
- Packaging5MG
- Price₹10846.65
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0374
- Product descriptionU-104 ≥98% (HPLC)
- Packaging25MG
- Price₹43830.43
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0374 | U-104 ≥98% (HPLC) | 5MG | ₹10846.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0374 | U-104 ≥98% (HPLC) | 25MG | ₹43830.43 | 2022-06-14 | Buy |
Properties
Melting point :242-243℃
Density :1.523±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :2-8°C
solubility :DMSO: >15mg/mL
form :powder
pka :9.94±0.12(Predicted)
color :white to beige
Density :1.523±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :2-8°C
solubility :DMSO: >15mg/mL
form :powder
pka :9.94±0.12(Predicted)
color :white to beige
Safety Information
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Description
Carbonic anhydrases are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to form bicarbonate ion plus a proton. Carbonic anhydrases IX (CAIX) and CAXII are hypoxia and HIF-1-inducible proteins located in cellular transmembranes that regulate intra- and extracellular pH under hypoxic conditions and promote tumor cell survival and invasion in hypoxic microenvironments. U-104 is a ureido-sulfonamide inhibitor of transmembrane CAIX (Ki = 45.1 nM) and CAXII (Ki = 4.5 nM). It demonstrates reduced affinity for the cytosolic isoforms, CAI and CAII (Kis = 5.08 and 9.64 μM, respectively). U-104 associates with CAIX/CAXII only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models.More related product prices
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