4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole
![4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole Structure](/CAS2/GIF/210690-85-0.gif)
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- Product name: 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole
- CAS: 210690-85-0
- MF: C30H57NO2SSi2
- MW: 552.02
- EINECS:
- MDL Number:MFCD04039436
- Synonyms:4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole;4-[(1E,3S,5Z,10S)-3,11-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2,6,10-triMethyl-1,5-undecadien-1-yl]-2-Methyl-thiazole;Thiazole, 4-[(1E,3S,5Z,10S)-3,11-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,6,10-trimethyl-1,5-undecadien-1-yl]-2-methyl-;Paclitaxel Impurity 75
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Properties
Boiling point :550.1±50.0 °C(Predicted)
Density :0.939±0.06 g/cm3(Predicted)
solubility :Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene
form :Oil
pka :2.73±0.10(Predicted)
color :Colourless
Density :0.939±0.06 g/cm3(Predicted)
solubility :Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene
form :Oil
pka :2.73±0.10(Predicted)
color :Colourless
Safety Information
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Description
An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.More related product prices
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