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Methylprednisolone hemisuccinate

Methylprednisolone hemisuccinate Structure
  • ₹0
  • Product name: Methylprednisolone hemisuccinate
  • CAS: 2921-57-5
  • MF: C26H34O8
  • MW: 474.54
  • EINECS:220-863-9
  • MDL Number:MFCD00271782
  • Synonyms:6-alpha-Methyl Isomer of Methylhydrocortisone 21-Hydrogen Succinate;11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-succinate;6a- methyl prednisolone acetate half Kohaku;4-diene-3,20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-21-(hy ;4-diene-3,20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-21-suc ;6-methylprednisolonehemisuccinate ;Methylprednisolone sucsinate;Methylprednisolone Hemisuccinate (200 mg)
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :>230°C (dec.)
Boiling point :689.6±55.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Practically insoluble in water, slightly soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides.
pka :4.29±0.17(Predicted)
form :Solid
color :White to Off-White
LogP :2.69
CAS DataBase Reference :2921-57-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Methylprednisolone is a synthetic glucocorticoid that has anti-inflammatory and immunosuppressant effects through the glucocorticoid receptor. The methyl group reduces specific binding to corticosteroid-binding globulin, which may allow better tissue penetration, compared to that of prednisolone. 6α-Methylprednisolone 21-hemisuccinate is a prodrug for methylprednisolone. This compound has superior water solubility compared to the active glucocorticoid.

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