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PROSTAGLANDINS F2ALPHA METHYL ESTER

PROSTAGLANDINS F2ALPHA METHYL ESTER Structure
  • ₹27993.45
  • Product name: PROSTAGLANDINS F2ALPHA METHYL ESTER
  • CAS: 33854-16-9
  • MF: C21H36O5
  • MW: 368.51
  • EINECS:201-185-2
  • MDL Number:MFCD00133790
  • Synonyms:(5Z,9S,11S,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid methyl ester;9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, METHYL ESTER;PGF2ALPHA-OME;PROSTAGLANDINS F2ALPHA METHYL ESTER;PROSTAGLANDIN F2ALPHA METHYL ESTER;(5Z,13E,15S)-9α,11α,15-Trihydroxyprosta-5,13-dien-1-oic acid methyl ester;(Z)-Methyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoate;13e,15s)-alph
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Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberP0314
  • Product descriptionProstaglandin F2α methyl ester ~5?mg/mL in methyl acetate, ≥95% (HPLC)
  • Packaging1MG
  • Price₹27993.45
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) P0314 Prostaglandin F2α methyl ester ~5?mg/mL in methyl acetate, ≥95% (HPLC) 1MG ₹27993.45 2022-06-14 Buy

Properties

Boiling point :418.83°C (rough estimate)
Density :1.0390 (rough estimate)
refractive index :1.6120 (estimate)
Flash point :-9 °C
storage temp. :−20°C
solubility :DMF: 35 mg/ml; DMSO: 35 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.4 mg/ml

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Prostaglandin F2α methyl ester (PGF2α methyl ester) is an analog of PGF2α in which the C-1 carboxyl group has been esterified as the methyl ester. PGF2α methyl ester was one of the first PG esters shown to have ocular hypotensive activity. This compound continues to be a standard by which other ocular hypotensive PG prodrugs are evaluated. The methyl ester is about 4-5 times more potent than the free acid, PGF2α. This difference is attributed to improved corneal penetration, and a depot effect of prolonged retention of the ester form of the compound in ocular tissue. A 2.5 μg dose of PGF2α-OMe applied to the eyes of cats results in a 6-8 mm Hg reduction in IOP.

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