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ChemicalBook > Product Catalogue >Biochemical Engineering >Protein Research >Protease inhibitors >4-Amidinophenylmethanesulfonyl fluoride hydrochloride

4-Amidinophenylmethanesulfonyl fluoride hydrochloride

4-Amidinophenylmethanesulfonyl fluoride hydrochloride Structure
  • ₹13630 - ₹42630
  • Product name: 4-Amidinophenylmethanesulfonyl fluoride hydrochloride
  • CAS: 74938-88-8
  • MF: C8H10ClFN2O2S
  • MW: 252.69
  • EINECS:
  • MDL Number:MFCD00036898
  • Synonyms:APMSF HCL;APMSF HYDROCHLORIDE;4-AMIDINOPHENYLMETHANESULFONYL FLUORIDE HYDROCHLORI;P-APMSF;P-APMSF, HYDROCHLORIDE;(P-AMIDINOPHENYL)METHANESULFONYL FLUORIDE HYDROCHLORIDE;P-AMIDINOPHENYLMETHYLSULFONYLFLUORIDE, HCL;P-AMIDINOPHENYLMETHYL-SULFONYLFLUORIDE HYDROCHLORIDE
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberA6664
  • Product description4-Amidinophenylmethanesulfonyl fluoride hydrochloride serine protease inhibitor
  • Packaging50MG
  • Price₹42630
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number178281
  • Product descriptionp-APMSF, Hydrochloride - CAS 74938-88-8 - Calbiochem Alternative to DFP and PMSF.
  • Packaging5MG
  • Price₹14260
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA6664
  • Product description4-Amidinophenylmethanesulfonyl fluoride hydrochloride serine protease inhibitor
  • Packaging10MG
  • Price₹13630
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) A6664 4-Amidinophenylmethanesulfonyl fluoride hydrochloride serine protease inhibitor 50MG ₹42630 2022-06-14 Buy
Sigma-Aldrich(India) 178281 p-APMSF, Hydrochloride - CAS 74938-88-8 - Calbiochem Alternative to DFP and PMSF. 5MG ₹14260 2022-06-14 Buy
Sigma-Aldrich(India) A6664 4-Amidinophenylmethanesulfonyl fluoride hydrochloride serine protease inhibitor 10MG ₹13630 2022-06-14 Buy

Properties

Melting point :~205 °C (dec.)
storage temp. :-20°C
solubility :H2O: 50 mM Stable when aliquoted at −20°C. Half-life = 6 minutes in pH 7.0 buffer systems.
form :White solid
BRN :9083148
InChIKey :KHLLRHIUKOJXLL-UHFFFAOYSA-N
CAS DataBase Reference :74938-88-8(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

Description

p-APMSF has been shown to be an irreversible and specific inhibitor of the class of plasma serine proteases which display substrate specificity for positively charged side chains of arginine and lysine amino acids. In addition, p-APMSF has been noted to be a protease inhibitor that blocks intracellular acidification, DNA fragmentation, and 5-Fluoro-2'-deoxyuridine induced cell death in mouse mammary tumor cells. This compound also demonstrates inhibitory abilities toward esterase activity in thrombin like enzymes. p-APMSF, Hydrochloride is an inhibitor of KLK11, Thrombin, Trypsin, C1r, C1s, Factor X and plasminogen.

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