AT9283
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- ₹0
- Product name: AT9283
- CAS: 896466-04-9
- MF: C19H23N7O2
- MW: 381.43
- EINECS:
- MDL Number:MFCD12031513
- Synonyms:1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea AT9283;AT9283, >=98%;N-cyclopropyl-N'-[3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]Urea;Urea, N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-;1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea;CS-48;AT-9283; AT 9283;J-504568
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Properties
Density :1.45
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :insoluble in H2O; ≥19.05 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
form :solid
pka :10.58±0.10(Predicted)
color :White to off-white
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :insoluble in H2O; ≥19.05 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
form :solid
pka :10.58±0.10(Predicted)
color :White to off-white
Safety Information
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Description
AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50s = 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits many other kinases, including serine/threonine kinases as well as receptor and non-receptor tyrosine kinases. As Aurora kinases have roles in mitosis, inhibitors of these kinases, including AT-9283, have potential in cancer therapy. Consistent with this, AT-9283 is effective in preventing proliferation of cancer cells both in vitro and in vivo and this effect may be enhanced by combination therapy with other chemotherapeutics.Related product price
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