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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Cell Cycle >Aurora Kinase Inhibitors >MK-5108 (VX-689)

MK-5108 (VX-689)

MK-5108 (VX-689) Structure
  • ₹0
  • Product name: MK-5108 (VX-689)
  • CAS: 1010085-13-8
  • MF: C22H21ClFN3O3S
  • MW: 461.94
  • EINECS:
  • MDL Number:MFCD22124479
  • Synonyms:trans-4-(3-Chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]cyclohexanecarboxylic acid;MK-5108(VX-689);(1r,4r)-4-(3-chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylaMino)pyridin-2-yl)Methyl)cyclohexanecarboxylic acid;MK-5198;MK 5108; VX-689; VX 689; MK5108; VX689;CS-545;Cyclohexanecarboxylic acid, 4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-, trans-;MK-5108 (VX-689) USP/EP/BP
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :637.6±65.0 °C(Predicted)
Density :1.429
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :≥23.1 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :solid
pka :4.41±0.44(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. MK-5108 is a potent inhibitor of Aurora A (IC50 = 0.064 nM). It less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM, respectively). MK-5108 blocks cell cycle progression and induces apoptosis in a diverse range of human tumor types. It is effective in vivo, inhibiting the growth of xenograft tumors in mice.

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