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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Antibiotics anticancer drugs >Actinomycin D

Actinomycin D

Actinomycin D Structure
  • ₹4384.13 - ₹121283.3
  • Product name: Actinomycin D
  • CAS: 50-76-0
  • MF: C62H86N12O16
  • MW: 1255.42
  • EINECS:200-063-6
  • MDL Number:MFCD00005033
  • Synonyms:2-Amino-N,N'-bis[hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide;Actinomycin D, Actinomycin IV, Actinomycin C1, Dactinomycin;Dactinomycin, DTM;Actinomycin C1, Dactinomycin;Actactinomycin A IV;Cosmogen;actinomycin7 ;actinomycinaiv
Price16 Properties Safety Information Description
16 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)
  • SRL

Package

  • 2MG
  • 5MG
  • 10MG
  • 25MG
  • 100MG
  • 1ML
  • ManufacturerSigma-Aldrich(India)
  • Product numberA1410
  • Product descriptionActinomycin D from Streptomyces sp., ~98% (HPLC)
  • Packaging25MG
  • Price₹42715.45
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA9415
  • Product descriptionActinomycin D from Streptomyces sp., suitable for cell culture, ≥95%
  • Packaging10MG
  • Price₹34704.95
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA4262
  • Product descriptionActinomycin D from Streptomyces sp., ≥95% (HPLC)
  • Packaging25MG
  • Price₹33081.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA1410
  • Product descriptionActinomycin D from Streptomyces sp., ~98% (HPLC)
  • Packaging10MG
  • Price₹18510.75
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA9415
  • Product descriptionActinomycin D from Streptomyces sp., suitable for cell culture, ≥95%
  • Packaging5MG
  • Price₹17785.48
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSBR00013
  • Product descriptionActinomycin D, Ready Made Solution from Streptomyces sp., 2?mg/mL in DMSO
  • Packaging1ML
  • Price₹15388.1
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA1410
  • Product descriptionActinomycin D from Streptomyces sp., ~98% (HPLC)
  • Packaging100MG
  • Price₹121283.3
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA9415
  • Product descriptionActinomycin D from Streptomyces sp., suitable for cell culture, ≥95%
  • Packaging25MG
  • Price₹54103.35
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA4262
  • Product descriptionActinomycin D from Streptomyces sp., ≥95% (HPLC)
  • Packaging10MG
  • Price₹15165.83
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA1410
  • Product descriptionActinomycin D from Streptomyces sp., ~98% (HPLC)
  • Packaging5MG
  • Price₹12275.55
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA1410
  • Product descriptionActinomycin D from Streptomyces sp., ~98% (HPLC)
  • Packaging2MG
  • Price₹11387.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA4262
  • Product descriptionActinomycin D from Streptomyces sp., ≥95% (HPLC)
  • Packaging5MG
  • Price₹8822.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA9415
  • Product descriptionActinomycin D from Streptomyces sp., suitable for cell culture, ≥95%
  • Packaging2MG
  • Price₹7772.35
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA4262
  • Product descriptionActinomycin D from Streptomyces sp., ≥95% (HPLC)
  • Packaging2MG
  • Price₹4384.13
  • Updated2022-06-14
  • Buy
  • ManufacturerSRL
  • Product number28269
  • Product descriptionActinomycin D (AMD) extrapure, 98%
  • Packaging2mg
  • Price₹5630
  • Updated2022-05-26
  • Buy
  • ManufacturerSRL
  • Product number28269
  • Product descriptionActinomycin D (AMD) extrapure, 98%
  • Packaging5mg
  • Price₹13200
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) A1410 Actinomycin D from Streptomyces sp., ~98% (HPLC) 25MG ₹42715.45 2022-06-14 Buy
Sigma-Aldrich(India) A9415 Actinomycin D from Streptomyces sp., suitable for cell culture, ≥95% 10MG ₹34704.95 2022-06-14 Buy
Sigma-Aldrich(India) A4262 Actinomycin D from Streptomyces sp., ≥95% (HPLC) 25MG ₹33081.2 2022-06-14 Buy
Sigma-Aldrich(India) A1410 Actinomycin D from Streptomyces sp., ~98% (HPLC) 10MG ₹18510.75 2022-06-14 Buy
Sigma-Aldrich(India) A9415 Actinomycin D from Streptomyces sp., suitable for cell culture, ≥95% 5MG ₹17785.48 2022-06-14 Buy
Sigma-Aldrich(India) SBR00013 Actinomycin D, Ready Made Solution from Streptomyces sp., 2?mg/mL in DMSO 1ML ₹15388.1 2022-06-14 Buy
Sigma-Aldrich(India) A1410 Actinomycin D from Streptomyces sp., ~98% (HPLC) 100MG ₹121283.3 2022-06-14 Buy
Sigma-Aldrich(India) A9415 Actinomycin D from Streptomyces sp., suitable for cell culture, ≥95% 25MG ₹54103.35 2022-06-14 Buy
Sigma-Aldrich(India) A4262 Actinomycin D from Streptomyces sp., ≥95% (HPLC) 10MG ₹15165.83 2022-06-14 Buy
Sigma-Aldrich(India) A1410 Actinomycin D from Streptomyces sp., ~98% (HPLC) 5MG ₹12275.55 2022-06-14 Buy
Sigma-Aldrich(India) A1410 Actinomycin D from Streptomyces sp., ~98% (HPLC) 2MG ₹11387.9 2022-06-14 Buy
Sigma-Aldrich(India) A4262 Actinomycin D from Streptomyces sp., ≥95% (HPLC) 5MG ₹8822.38 2022-06-14 Buy
Sigma-Aldrich(India) A9415 Actinomycin D from Streptomyces sp., suitable for cell culture, ≥95% 2MG ₹7772.35 2022-06-14 Buy
Sigma-Aldrich(India) A4262 Actinomycin D from Streptomyces sp., ≥95% (HPLC) 2MG ₹4384.13 2022-06-14 Buy
SRL 28269 Actinomycin D (AMD) extrapure, 98% 2mg ₹5630 2022-05-26 Buy
SRL 28269 Actinomycin D (AMD) extrapure, 98% 5mg ₹13200 2022-05-26 Buy

Properties

Melting point :251-253 °C
Boiling point :848°C (rough estimate)
Density :1.0757 (rough estimate)
refractive index :1.5700 (estimate)
Flash point :87℃
storage temp. :2-8°C
solubility :ethanol, DMSO: Stable in aqueous solutions at 2-8 °C.soluble
pka :8.94±0.70(Predicted)
form :powder
color :red, powder
optical activity :[α]/D alpha: 28/D (Rotation: -315 degrees (c=0.25% in methanol))
Water Solubility :SOLUBLE
Merck :13,2828
BRN :605235
Stability :Stable, but light sensitive, especially in dilute solution. Incompatible with strong acids, strong bases, strong oxidizing agents. Combustible.
CAS DataBase Reference :50-76-0(CAS DataBase Reference)
IARC :3 (Vol. 10, Sup 7) 1987
EPA Substance Registry System :Actinomycin D (50-76-0)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks transcription. It binds to pre-melted double-stranded DNA in transcription bubbles and once bound is slow to dissociate. DNA in transcriptionally hyperactive cancer cells efficiently and rapidly bind actinomycin D at low concentrations (~10 nM), which interferes with RNA synthesis and ultimately leads to cell death. Actinomycin D is widely used as an anticancer agent for treating a variety of tumors and along with its fluorescent derivative, 7-aminoactinomycin D has become a useful tool in biochemistry and molecular biology research as a marker for DNA.

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Suppliers and manufacturers

Concord Biotech Limited Euroasia Trans Continental CONCORD BIOTECH LTD CHEMSWORTH CLEARSYNTH LABS LTD. Maas Pharma Chemicals Sisco Research Laboratories Pvt. Ltd. Triveni chemicals Pharmaffiliates Analytics and Synthetics P. Ltd Medicea Impex Private Limited