Amifostine
- ₹0
- Product name: Amifostine
- CAS: 20537-88-6
- MF: C5H15N2O3PS
- MW: 214.22
- EINECS:633-786-4
- MDL Number:MFCD00233058
- Synonyms:γphos;Fosteamine;2-(3-Aminopropyl)aminoethyl phosphorothioate, WR2721;Ethiotas;S-2-[(3-Aminopropyl)amino]ethanethiol dihydrogen phosphate ester;Amifostine,2-(3-Aminopropyl)aminoethyl phosphorothioate, WR2721;AMifostine anhydrous;AMifostine(Ethiofos)
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Properties
Melting point :160-1610C
Boiling point :441.7±51.0 °C(Predicted)
Density :1.367±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in Water.
form :powder
pka :1.28±0.10(Predicted)
color :White
Water Solubility :Soluble to 100 mM in water
Stability :Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference :20537-88-6(CAS DataBase Reference)
Boiling point :441.7±51.0 °C(Predicted)
Density :1.367±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in Water.
form :powder
pka :1.28±0.10(Predicted)
color :White
Water Solubility :Soluble to 100 mM in water
Stability :Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference :20537-88-6(CAS DataBase Reference)
Safety Information
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Description
Amifostine, an organic thiophosphate, was introduced for the reduction of cisplatin-induced renal toxicity in patients with advanced ovarian cancer. It is also a radio-protective agent. Amifostine is a prodrug which is rapidly dephosphorylated, preferentially in non-tumor tissues to the active thiol. This agent binds to chemotherapeutic drugs and free radicals released by radiotherapy. The protective effect of amifostine was observed in a wide range of normal organs including bone marrow and gastrointestinal mucosa without interfering with the anti-tumor effect of chemohadiotherapy, indicating an increased therapeutic index for existing cancer treatment. Amifostine is also being evaluated as a cytoprotective in other types of tumors including lung, breast, head and neck cancers. It was reported to be a potent mucolytic with potential in cystic fibrosis.Related product price
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