Anifostine trihydrate
|
- ₹25817.63 - ₹58920.48
- Product name: Anifostine trihydrate
- CAS: 112901-68-5
- MF: C5H17N2O4PS
- MW: 232.23
- EINECS:
- MDL Number:MFCD00233058
- Synonyms:Amifostine (150 mg);Anifostine trihydrate;Ethanethiol,2-[(3-aMinopropyl)aMino]-, 1-(dihydrogen phosphate), hydrate (1:3);Amifostine trihydrate, >=98%;Aminopropylamino)ethylsulfanylphosphonic acid trihydrate;S-2-(3-AMINOPROPYLAMINO)ETHYL O,O-DIHYDROGEN PHOSPHOROTHIOATE;WR2721;Amifostinetrihydrateormonohydrate
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 100MG
- 300MG
- ManufacturerSigma-Aldrich(India)
- Product numberPHR2940
- Product descriptionAmifostine pharmaceutical secondary standard, certified reference material
- Packaging300MG
- Price₹25817.63
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberA5922
- Product descriptionAmifostine trihydrate ≥97% (TLC), powder
- Packaging100MG
- Price₹58920.48
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2940 | Amifostine pharmaceutical secondary standard, certified reference material | 300MG | ₹25817.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A5922 | Amifostine trihydrate ≥97% (TLC), powder | 100MG | ₹58920.48 | 2022-06-14 | Buy |
Properties
storage temp. :2-8°C
solubility :PBS (pH 7.2): 5 mg/ml
form :powder
pka :pKa1 <2.0; pKa2 4.2; pKa3 9.0; pKa4 11.7(at 25℃)
color :White to off-white
InChIKey :JKOQGQFVAUAYPM-UHFFFAOYSA-N
CAS DataBase Reference :112901-68-5(CAS DataBase Reference)
solubility :PBS (pH 7.2): 5 mg/ml
form :powder
pka :pKa1 <2.0; pKa2 4.2; pKa3 9.0; pKa4 11.7(at 25℃)
color :White to off-white
InChIKey :JKOQGQFVAUAYPM-UHFFFAOYSA-N
CAS DataBase Reference :112901-68-5(CAS DataBase Reference)
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
Amifostine is a prodrug that through dephosphorylation by alkaline phosphatase is converted to an active thiol, WR 1065 that has free radical scavenging, DNA protective, and hypoxia inducing activities. Because of the differential expression of alkaline phosphatase in normal versus neoplastic tissues, the cytoprotection conferred by amifostine is selective, enabling as much as 100-fold greater accumulation of WR 1065 in normal tissues than in tumor cells. Amifostine has been used to reduce toxicity in normal tissues exposed to radiation or chemotherapeutic agents. In mouse fibroblasts and various cancer cells, amifostine (IC50 = 4 mM) has been shown to activate p53 protein, to induce the expression of the cyclin-dependent kinase inhibitor p21, and to arrest cells at the G1/S transition through a p53-dependent mechanism.More related product prices
Dexrazoxane Fluorescein disodium salt CHAETOMIN QUINOMYCIN A Chrysin Docetaxel Gemcitabine hydrochloride 331830-20-7 112901-68-5 Amifostine EthanethiolRelated product price
- Dexrazoxane
₹5700-42325.75 - Fluorescein disodium salt
₹320-44760 - CHAETOMIN
₹25503.7-76695.13