QUINOMYCIN A
|
- ₹13996.73 - ₹59526.68
- Product name: QUINOMYCIN A
- CAS: 512-64-1
- MF: C51H64N12O12S2
- MW: 1101.26
- EINECS:
- MDL Number:MFCD00156105
- Synonyms:echinomycina ;nsc526417 ;ECHINOMYCIN;N-[(1R,4S,8R,11S,14R,17S,21R,24S)-3,11,13,16,24,26-hexamethyl-27-methylsulfanyl-2,5,9,12,15,18,22,25-octaoxo-4,17-di(propan-2-yl)-8-(quinoxaline-2-carbonylamino)-6,19-dioxa-28-thia-3,10,13,16,23,26-hexazabicyclo[12.12.3]nonacosan-21-yl]quinoxaline-2-carbo;N-(2-Quinoxalinylcarbonyl)cyclo(D-Ser*-Ala-N-methyl-L-Cys(1)-N-methyl-L-Val-N-(quinoxaline-2-ylcarbonyl)-D-Ser*-Ala-N-methyl-3-methylthio-L-Ala(1)-N-methyl-L-Val-);SK-302B;Echinomycin >97%;N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl L-valine (81)-lactone cyclic (37)-thioester
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0477
- Product descriptionEchinomycin ≥98% (HPLC)
- Packaging1MG
- Price₹13996.73
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0477
- Product descriptionEchinomycin ≥98% (HPLC)
- Packaging5MG
- Price₹59526.68
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0477 | Echinomycin ≥98% (HPLC) | 1MG | ₹13996.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0477 | Echinomycin ≥98% (HPLC) | 5MG | ₹59526.68 | 2022-06-14 | Buy |
Properties
Melting point :217-218℃
alpha :D20 -310° (c = 0.86 in chloroform)
Boiling point :1427.2±65.0 °C(Predicted)
Density :1.0964 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 5 mg/ml)
pka :9.38±0.70(Predicted)
form :White solid
color :white to beige
Merck :13,3531
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
alpha :D20 -310° (c = 0.86 in chloroform)
Boiling point :1427.2±65.0 °C(Predicted)
Density :1.0964 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 5 mg/ml)
pka :9.38±0.70(Predicted)
form :White solid
color :white to beige
Merck :13,3531
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
Safety Information
| Symbol(GHS): |
 
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription. It acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1α or HIF-1β to the hypoxia-responsive element. Echinomycin reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC50 value of 1.2 nM. It inhibits hypoxia-induced expression of vascular endothelial growth factor, blocking angiogenesis and altering excitatory synaptic transmission in hippocampal neurons. Echinomycin also impairs expression of survivin, enhancing the sensitivity of multiple myeloma cells to melphalan.More related product prices
CHAETOMIN 112901-68-5 Chrysin Azithromycin Imatinib mesylate Geldanamycin Sunitinib Malate 331830-20-7 2-QUINOXALINECARBALDEHYDERelated product price
- CHAETOMIN
₹25503.7-76695.13 - 112901-68-5
₹25817.63-58920.48 - Chrysin
₹1899-96003